Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients
Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of <i>Aspergillus fumigatus</i> in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/2/152 |
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| author | Mireille H. van der Torre Hongwei Shen Riina Rautemaa-Richardson Malcolm D. Richardson Lilyann Novak-Frazer |
| author_facet | Mireille H. van der Torre Hongwei Shen Riina Rautemaa-Richardson Malcolm D. Richardson Lilyann Novak-Frazer |
| author_sort | Mireille H. van der Torre |
| collection | DOAJ |
| description | Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of <i>Aspergillus fumigatus</i> in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other <i>Aspergillus</i> conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience. |
| first_indexed | 2024-03-09T00:40:57Z |
| format | Article |
| id | doaj.art-b9c4d843317849c59a3e9347799c6c38 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T00:40:57Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b9c4d843317849c59a3e9347799c6c382023-12-11T17:50:20ZengMDPI AGJournal of Fungi2309-608X2021-02-017215210.3390/jof7020152Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis PatientsMireille H. van der Torre0Hongwei Shen1Riina Rautemaa-Richardson2Malcolm D. Richardson3Lilyann Novak-Frazer4Mycology Reference Centre Manchester, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester M23 9LT, UKDivision of Infection, Inflammation and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UKMycology Reference Centre Manchester, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester M23 9LT, UKMycology Reference Centre Manchester, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester M23 9LT, UKMycology Reference Centre Manchester, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester M23 9LT, UKMolecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of <i>Aspergillus fumigatus</i> in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other <i>Aspergillus</i> conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience.https://www.mdpi.com/2309-608X/7/2/152<i>Aspergillus fumigatus</i>molecular epidemiologychronic pulmonary aspergillosisgenotypinggenetic diversity |
| spellingShingle | Mireille H. van der Torre Hongwei Shen Riina Rautemaa-Richardson Malcolm D. Richardson Lilyann Novak-Frazer Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients Journal of Fungi <i>Aspergillus fumigatus</i> molecular epidemiology chronic pulmonary aspergillosis genotyping genetic diversity |
| title | Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients |
| title_full | Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients |
| title_fullStr | Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients |
| title_full_unstemmed | Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients |
| title_short | Molecular Epidemiology of <i>Aspergillus fumigatus</i> in Chronic Pulmonary Aspergillosis Patients |
| title_sort | molecular epidemiology of i aspergillus fumigatus i in chronic pulmonary aspergillosis patients |
| topic | <i>Aspergillus fumigatus</i> molecular epidemiology chronic pulmonary aspergillosis genotyping genetic diversity |
| url | https://www.mdpi.com/2309-608X/7/2/152 |
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