Advances in transdermal siRNAs delivery: A review of current research progress
Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend the genome from invasive nucleic acids. The use of siRNAs has been studied as a treatment option f...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000331 |
| _version_ | 1797791902787960832 |
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| author | Albert Sufianov Aferin Beilerli Valentin Kudriashov Tatiana Ilyasova Bu Wenjie Ozal Beylerli |
| author_facet | Albert Sufianov Aferin Beilerli Valentin Kudriashov Tatiana Ilyasova Bu Wenjie Ozal Beylerli |
| author_sort | Albert Sufianov |
| collection | DOAJ |
| description | Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend the genome from invasive nucleic acids. The use of siRNAs has been studied as a treatment option for various skin conditions. One of the main obstacles in the dermal or transdermal delivery of this compound is low skin permeability, and application is limited by its negative charge, high polarity, susceptibility to degradation by nucleases, and difficulty in penetrating the skin barrier. Effective delivery of therapeutic biomolecules to their target is a challenging issue, which can be solved by innovations in drug delivery systems and lead to improvement of the efficiency of many new biopharmaceuticals. Designing of novel transdermal delivery systems garnered tremendous attention in both cosmeceutical and pharmaceutical research and industries, which offers a number of advantages. Developing safe and efficient siRNAs delivery vectors is essential for effective treatment of skin diseases. In recent years, significant progress has been made in the creation of delivery systems using lipids, polymers, cell-penetrating peptides, nanoparticles and other biologically active agents. In this review we will focus on the recent advancements in transdermal siRNAs delivery vectors, such as liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles. |
| first_indexed | 2024-03-13T02:25:25Z |
| format | Article |
| id | doaj.art-b9c51d3375aa492bab2ffff9d903c283 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-03-13T02:25:25Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-b9c51d3375aa492bab2ffff9d903c2832023-06-30T04:22:35ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-09-0183392400Advances in transdermal siRNAs delivery: A review of current research progressAlbert Sufianov0Aferin Beilerli1Valentin Kudriashov2Tatiana Ilyasova3Bu Wenjie4Ozal Beylerli5Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaDepartment of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaGastric Cancer Center, West China Hospital of Sichuan University, ChinaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, RussiaDepartment of Pharmacology, College of Pharmacy, Harbin Medical University, 157 Baojian Rd, Nangang, Harbin, Heilongjiang, 150088, ChinaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Corresponding author. Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend the genome from invasive nucleic acids. The use of siRNAs has been studied as a treatment option for various skin conditions. One of the main obstacles in the dermal or transdermal delivery of this compound is low skin permeability, and application is limited by its negative charge, high polarity, susceptibility to degradation by nucleases, and difficulty in penetrating the skin barrier. Effective delivery of therapeutic biomolecules to their target is a challenging issue, which can be solved by innovations in drug delivery systems and lead to improvement of the efficiency of many new biopharmaceuticals. Designing of novel transdermal delivery systems garnered tremendous attention in both cosmeceutical and pharmaceutical research and industries, which offers a number of advantages. Developing safe and efficient siRNAs delivery vectors is essential for effective treatment of skin diseases. In recent years, significant progress has been made in the creation of delivery systems using lipids, polymers, cell-penetrating peptides, nanoparticles and other biologically active agents. In this review we will focus on the recent advancements in transdermal siRNAs delivery vectors, such as liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles.http://www.sciencedirect.com/science/article/pii/S2468054023000331RNA interferenceSmall interfering RNADelivery vectorSkin diseasesLipidosomePolymers |
| spellingShingle | Albert Sufianov Aferin Beilerli Valentin Kudriashov Tatiana Ilyasova Bu Wenjie Ozal Beylerli Advances in transdermal siRNAs delivery: A review of current research progress Non-coding RNA Research RNA interference Small interfering RNA Delivery vector Skin diseases Lipidosome Polymers |
| title | Advances in transdermal siRNAs delivery: A review of current research progress |
| title_full | Advances in transdermal siRNAs delivery: A review of current research progress |
| title_fullStr | Advances in transdermal siRNAs delivery: A review of current research progress |
| title_full_unstemmed | Advances in transdermal siRNAs delivery: A review of current research progress |
| title_short | Advances in transdermal siRNAs delivery: A review of current research progress |
| title_sort | advances in transdermal sirnas delivery a review of current research progress |
| topic | RNA interference Small interfering RNA Delivery vector Skin diseases Lipidosome Polymers |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000331 |
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