The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study
Background and aimsCardiac enzymes are recognized as a valuable tool for predicting the prognosis of various cardiovascular diseases. The prognostic value of alpha-hydroxybutyrate dehydrogenase (α-HBDH) in patients with intracerebral hemorrhage (ICH) was ambiguous and not evaluated.MethodsTwo hundre...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.906249/full |
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| author | Zhang Limin Zhang Limin Zhang Limin Rasha Alsamani Rasha Alsamani Rasha Alsamani Wu Jianwei Shi Yijun Shi Yijun Shi Yijun Wang Dan Wang Dan Wang Dan Sun Yuehong Sun Yuehong Sun Yuehong Liu Ziwei Liu Ziwei Liu Ziwei Xu Huiwen Xu Huiwen Xu Huiwen Wang Dongzhi Wang Dongzhi Wang Dongzhi Zhao Xingquan Zhang Guojun Zhang Guojun Zhang Guojun |
| author_facet | Zhang Limin Zhang Limin Zhang Limin Rasha Alsamani Rasha Alsamani Rasha Alsamani Wu Jianwei Shi Yijun Shi Yijun Shi Yijun Wang Dan Wang Dan Wang Dan Sun Yuehong Sun Yuehong Sun Yuehong Liu Ziwei Liu Ziwei Liu Ziwei Xu Huiwen Xu Huiwen Xu Huiwen Wang Dongzhi Wang Dongzhi Wang Dongzhi Zhao Xingquan Zhang Guojun Zhang Guojun Zhang Guojun |
| author_sort | Zhang Limin |
| collection | DOAJ |
| description | Background and aimsCardiac enzymes are recognized as a valuable tool for predicting the prognosis of various cardiovascular diseases. The prognostic value of alpha-hydroxybutyrate dehydrogenase (α-HBDH) in patients with intracerebral hemorrhage (ICH) was ambiguous and not evaluated.MethodsTwo hundred and thirteen Chinese patients with ICH participated in the study from December 2018 to December 2019. Laboratory routine tests and cardiac enzymes, including α-HBDH level, were examined and analyzed. All the patients were classified into two groups by the median value of α-HBDH: B1 <175.90 and B2 ≥175.90 U/L. The clinical outcomes included functional outcome (according to modified Rankin Scale (mRS) score ≥3), all-cause death, and recurrent cerebro-cardiovascular events 1 year after discharge. Associations between the α-HBDH and the outcomes were evaluated using logistic regression analysis. Univariate survival analysis was performed by the Kaplan–Meier method and log-rank test.ResultsOf the 213 patients, 117 had α-HBDH ≥175.90 U/L. Eighty-two patients had poor functional outcomes (mRS≥3). During the 1-year follow-up, a total of 20 patients died, and 15 of them had α-HBDH ≥175.90 U/L during the follow-up time. Moreover, 24 recurrent events were recorded. After adjusting confounding factors, α-HBDH (≥175.90) remained an indicator of poor outcome (mRS 3-6), all-cause death, and recurrent cerebro-cardiovascular events. The ORs for B2 vs. B1 were 4.78 (95% CI: 2.60 to 8.78, P = 0.001), 2.63 (95% CI: 0.80 to 8.59, P = 0.11), and 2.40 (95% CI: 0.82 to 7.02, P = 0.11) for poor functional outcomes with mRS ≥ 3, all-cause death, and recurrent cerebro-cardiovascular events, respectively.ConclusionIncreased α-HBDH at admission was independently related to poor functional outcome and all-cause mortality in patients with ICH at 1-year follow-up. |
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| spelling | doaj.art-b9c5d677d49047b399b3a1cd1d3d56412022-12-22T04:32:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.906249906249The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective studyZhang Limin0Zhang Limin1Zhang Limin2Rasha Alsamani3Rasha Alsamani4Rasha Alsamani5Wu Jianwei6Shi Yijun7Shi Yijun8Shi Yijun9Wang Dan10Wang Dan11Wang Dan12Sun Yuehong13Sun Yuehong14Sun Yuehong15Liu Ziwei16Liu Ziwei17Liu Ziwei18Xu Huiwen19Xu Huiwen20Xu Huiwen21Wang Dongzhi22Wang Dongzhi23Wang Dongzhi24Zhao Xingquan25Zhang Guojun26Zhang Guojun27Zhang Guojun28Department of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaNMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Beijing, ChinaBeijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, ChinaBackground and aimsCardiac enzymes are recognized as a valuable tool for predicting the prognosis of various cardiovascular diseases. The prognostic value of alpha-hydroxybutyrate dehydrogenase (α-HBDH) in patients with intracerebral hemorrhage (ICH) was ambiguous and not evaluated.MethodsTwo hundred and thirteen Chinese patients with ICH participated in the study from December 2018 to December 2019. Laboratory routine tests and cardiac enzymes, including α-HBDH level, were examined and analyzed. All the patients were classified into two groups by the median value of α-HBDH: B1 <175.90 and B2 ≥175.90 U/L. The clinical outcomes included functional outcome (according to modified Rankin Scale (mRS) score ≥3), all-cause death, and recurrent cerebro-cardiovascular events 1 year after discharge. Associations between the α-HBDH and the outcomes were evaluated using logistic regression analysis. Univariate survival analysis was performed by the Kaplan–Meier method and log-rank test.ResultsOf the 213 patients, 117 had α-HBDH ≥175.90 U/L. Eighty-two patients had poor functional outcomes (mRS≥3). During the 1-year follow-up, a total of 20 patients died, and 15 of them had α-HBDH ≥175.90 U/L during the follow-up time. Moreover, 24 recurrent events were recorded. After adjusting confounding factors, α-HBDH (≥175.90) remained an indicator of poor outcome (mRS 3-6), all-cause death, and recurrent cerebro-cardiovascular events. The ORs for B2 vs. B1 were 4.78 (95% CI: 2.60 to 8.78, P = 0.001), 2.63 (95% CI: 0.80 to 8.59, P = 0.11), and 2.40 (95% CI: 0.82 to 7.02, P = 0.11) for poor functional outcomes with mRS ≥ 3, all-cause death, and recurrent cerebro-cardiovascular events, respectively.ConclusionIncreased α-HBDH at admission was independently related to poor functional outcome and all-cause mortality in patients with ICH at 1-year follow-up.https://www.frontiersin.org/articles/10.3389/fneur.2022.906249/fullintracerebral hemorrhageoutcomesmortalityα-HBDHcardiovascular events |
| spellingShingle | Zhang Limin Zhang Limin Zhang Limin Rasha Alsamani Rasha Alsamani Rasha Alsamani Wu Jianwei Shi Yijun Shi Yijun Shi Yijun Wang Dan Wang Dan Wang Dan Sun Yuehong Sun Yuehong Sun Yuehong Liu Ziwei Liu Ziwei Liu Ziwei Xu Huiwen Xu Huiwen Xu Huiwen Wang Dongzhi Wang Dongzhi Wang Dongzhi Zhao Xingquan Zhang Guojun Zhang Guojun Zhang Guojun The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study Frontiers in Neurology intracerebral hemorrhage outcomes mortality α-HBDH cardiovascular events |
| title | The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study |
| title_full | The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study |
| title_fullStr | The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study |
| title_full_unstemmed | The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study |
| title_short | The relationship of α-hydroxybutyrate dehydrogenase with 1-year outcomes in patients with intracerebral hemorrhage: A retrospective study |
| title_sort | relationship of α hydroxybutyrate dehydrogenase with 1 year outcomes in patients with intracerebral hemorrhage a retrospective study |
| topic | intracerebral hemorrhage outcomes mortality α-HBDH cardiovascular events |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.906249/full |
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