High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya
Abstract Background Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline HPV genotype distributions and risk factors can inform the design of ne...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.6008 |
| _version_ | 1797775579077935104 |
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| author | Myo Minn Oo Samantha Moore Suzanne Gibbons Wendy Adhiambo Peter Muthoga Naomi Siele Maureen Akolo Henok Gebrebrhan Aida Sivro Blake T. Ball Robert R. Lorway Alberto Severini Joshua Kimani Lyle R. McKinnon |
| author_facet | Myo Minn Oo Samantha Moore Suzanne Gibbons Wendy Adhiambo Peter Muthoga Naomi Siele Maureen Akolo Henok Gebrebrhan Aida Sivro Blake T. Ball Robert R. Lorway Alberto Severini Joshua Kimani Lyle R. McKinnon |
| author_sort | Myo Minn Oo |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline HPV genotype distributions and risk factors can inform the design of next‐generation HPV vaccines to prevent anal cancer. Methods A cross‐sectional study was conducted among gbMSM receiving care at a HIV/STI clinic in Nairobi, Kenya. Anal swabs were genotyped using a Luminex microsphere array. Multiple logistic regression methods were used to identify risk factors for four HPV outcomes (any HPV, any HR‐HPV, and 4‐ and 9‐valent vaccine‐preventable HPVs). Results Among 115 gbMSM, 51 (44.3%) were HIV‐infected. Overall HPV prevalence was 51.3%; 84.3% among gbMSM living with HIV and 24.6% among gbMSM without HIV (p < 0.001). One‐third (32.2%) had HR‐HPV and the most prevalent vaccine‐preventable HR‐HPV genotypes were 16, 35, 45, and 58. HPV‐18 was uncommon (n = 2). The 9‐valent Gardasil vaccine would have prevented 61.0% of HPV types observed in this population. In multivariate analyses, HIV status was the only significant risk factor for any HPV (adjusted odds ratio [aOR]:23.0, 95% confidence interval [95% CI]: 7.3–86.0, p < 0.001) and for HR‐HPV (aOR: 8.9, 95% CI: 2.8–36.0, p < 0.001). Similar findings were obtained for vaccine‐preventable HPVs. Being married to a woman significantly increased the odds of having HR‐HPV infections (aOR: 8.1, 95% CI: 1.6–52.0, p = 0.016). Conclusions GbMSM living with HIV in Kenya are at higher risk of anal HPV infections including genotypes that are preventable with available vaccines. Our findings support the need for a targeted HPV vaccination campaign in this population. |
| first_indexed | 2024-03-12T22:37:42Z |
| format | Article |
| id | doaj.art-b9c72f0c35994fb09b95cbee56c3d1f5 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-12T22:37:42Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-b9c72f0c35994fb09b95cbee56c3d1f52023-07-21T11:20:58ZengWileyCancer Medicine2045-76342023-06-011212137451375710.1002/cam4.6008High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, KenyaMyo Minn Oo0Samantha Moore1Suzanne Gibbons2Wendy Adhiambo3Peter Muthoga4Naomi Siele5Maureen Akolo6Henok Gebrebrhan7Aida Sivro8Blake T. Ball9Robert R. Lorway10Alberto Severini11Joshua Kimani12Lyle R. McKinnon13Department of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaInstitute for Global Public Health (IGPH) University of Manitoba Winnipeg Manitoba CanadaJC Wilt Infectious Disease Research Centre National Microbiology Laboratory, Public Health Agency of Canada Winnipeg Manitoba CanadaUniversity of Nairobi Institute of Tropical and Infectious Diseases, University of Nairobi Nairobi KenyaUniversity of Nairobi Institute of Tropical and Infectious Diseases, University of Nairobi Nairobi KenyaUniversity of Nairobi Institute of Tropical and Infectious Diseases, University of Nairobi Nairobi KenyaUniversity of Nairobi Institute of Tropical and Infectious Diseases, University of Nairobi Nairobi KenyaDepartment of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaJC Wilt Infectious Disease Research Centre National Microbiology Laboratory, Public Health Agency of Canada Winnipeg Manitoba CanadaDepartment of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaInstitute for Global Public Health (IGPH) University of Manitoba Winnipeg Manitoba CanadaDepartment of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaDepartment of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaDepartment of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba CanadaAbstract Background Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline HPV genotype distributions and risk factors can inform the design of next‐generation HPV vaccines to prevent anal cancer. Methods A cross‐sectional study was conducted among gbMSM receiving care at a HIV/STI clinic in Nairobi, Kenya. Anal swabs were genotyped using a Luminex microsphere array. Multiple logistic regression methods were used to identify risk factors for four HPV outcomes (any HPV, any HR‐HPV, and 4‐ and 9‐valent vaccine‐preventable HPVs). Results Among 115 gbMSM, 51 (44.3%) were HIV‐infected. Overall HPV prevalence was 51.3%; 84.3% among gbMSM living with HIV and 24.6% among gbMSM without HIV (p < 0.001). One‐third (32.2%) had HR‐HPV and the most prevalent vaccine‐preventable HR‐HPV genotypes were 16, 35, 45, and 58. HPV‐18 was uncommon (n = 2). The 9‐valent Gardasil vaccine would have prevented 61.0% of HPV types observed in this population. In multivariate analyses, HIV status was the only significant risk factor for any HPV (adjusted odds ratio [aOR]:23.0, 95% confidence interval [95% CI]: 7.3–86.0, p < 0.001) and for HR‐HPV (aOR: 8.9, 95% CI: 2.8–36.0, p < 0.001). Similar findings were obtained for vaccine‐preventable HPVs. Being married to a woman significantly increased the odds of having HR‐HPV infections (aOR: 8.1, 95% CI: 1.6–52.0, p = 0.016). Conclusions GbMSM living with HIV in Kenya are at higher risk of anal HPV infections including genotypes that are preventable with available vaccines. Our findings support the need for a targeted HPV vaccination campaign in this population.https://doi.org/10.1002/cam4.6008anal HPVbisexualgay and men who have sex with men (gbMSM)HIV/STIHPV genotypesHPV vaccination |
| spellingShingle | Myo Minn Oo Samantha Moore Suzanne Gibbons Wendy Adhiambo Peter Muthoga Naomi Siele Maureen Akolo Henok Gebrebrhan Aida Sivro Blake T. Ball Robert R. Lorway Alberto Severini Joshua Kimani Lyle R. McKinnon High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya Cancer Medicine anal HPV bisexual gay and men who have sex with men (gbMSM) HIV/STI HPV genotypes HPV vaccination |
| title | High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya |
| title_full | High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya |
| title_fullStr | High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya |
| title_full_unstemmed | High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya |
| title_short | High prevalence of vaccine‐preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya |
| title_sort | high prevalence of vaccine preventable anal human papillomavirus infections is associated with hiv infection among gay bisexual and men who have sex with men in nairobi kenya |
| topic | anal HPV bisexual gay and men who have sex with men (gbMSM) HIV/STI HPV genotypes HPV vaccination |
| url | https://doi.org/10.1002/cam4.6008 |
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