Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials
Objective: To systematically review literature enabling the comparison of the efficacy of pharmaceutical treatments for tinea pedis in adults. Design: Systematic review of randomised controlled trials (RCTs) with mycological cure as the primary outcome. Secondary outcomes did include the clinical as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/4/351 |
| _version_ | 1797445557950611456 |
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| author | Harry Ward Nicholas Parkes Carolyn Smith Stefan Kluzek Richard Pearson |
| author_facet | Harry Ward Nicholas Parkes Carolyn Smith Stefan Kluzek Richard Pearson |
| author_sort | Harry Ward |
| collection | DOAJ |
| description | Objective: To systematically review literature enabling the comparison of the efficacy of pharmaceutical treatments for tinea pedis in adults. Design: Systematic review of randomised controlled trials (RCTs) with mycological cure as the primary outcome. Secondary outcomes did include the clinical assessment of resolving infection or symptoms, duration of treatment, adverse events, adherence, and recurrence. Eligibility Criteria: Study participants suffering from only tinea pedis that were treated with a pharmaceutical treatment. The study must have been conducted using an RCT study design and recording age of the participant > 16 years of age. Results: A total of seven studies met the inclusion criteria, involving 1042 participants. The likelihood of resolution in study participants treated with terbinafine was RR 3.9 (95% CI: 2.0–7.8) times those with a placebo. Similarly, the allylamine butenafine was effective by RR 5.3 (95% CI: 1.4–19.6) compared to a placebo. Butenafine was similarly efficacious to terbinafine RR 1.3 (95% CI: 0.4–4.4). Terbinafine was marginally more efficacious than itraconazole, RR 1.3 (95% CI: 1.1–1.5). Summary/Conclusion: Topical terbinafine and butenafine treatments of tinea pedis were more efficacious than placebo. Tableted terbinafine and itraconazole administered orally were efficacious in the drug treatment of tinea pedis fungal infection. We are concerned about how few studies were available that reported the baseline characteristics for each treatment arm and that did not suffer greater than 20% loss to follow-up. We would like to see improved reporting of clinical trials in academic literature. Registration name: Treatment’s for athlete’s foot—systematic review with meta-analysis [CRD42020162078]. |
| first_indexed | 2024-03-09T13:27:33Z |
| format | Article |
| id | doaj.art-b9c897027b61467c8c14af3e6a0d2375 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T13:27:33Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b9c897027b61467c8c14af3e6a0d23752023-11-30T21:21:52ZengMDPI AGJournal of Fungi2309-608X2022-03-018435110.3390/jof8040351Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled TrialsHarry Ward0Nicholas Parkes1Carolyn Smith2Stefan Kluzek3Richard Pearson4Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham NG7 2UH, UKVersus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham NG7 2UH, UKBodleian Health Care Libraries, Oxford University, Oxford OX3 9DU, UKOrthopaedics, Trauma and Sports Medicine, School of Medicine, Queen’s Medical, Centre University of Nottingham, Nottingham NG7 2UH, UKOrthopaedics, Trauma and Sports Medicine, School of Medicine, Queen’s Medical, Centre University of Nottingham, Nottingham NG7 2UH, UKObjective: To systematically review literature enabling the comparison of the efficacy of pharmaceutical treatments for tinea pedis in adults. Design: Systematic review of randomised controlled trials (RCTs) with mycological cure as the primary outcome. Secondary outcomes did include the clinical assessment of resolving infection or symptoms, duration of treatment, adverse events, adherence, and recurrence. Eligibility Criteria: Study participants suffering from only tinea pedis that were treated with a pharmaceutical treatment. The study must have been conducted using an RCT study design and recording age of the participant > 16 years of age. Results: A total of seven studies met the inclusion criteria, involving 1042 participants. The likelihood of resolution in study participants treated with terbinafine was RR 3.9 (95% CI: 2.0–7.8) times those with a placebo. Similarly, the allylamine butenafine was effective by RR 5.3 (95% CI: 1.4–19.6) compared to a placebo. Butenafine was similarly efficacious to terbinafine RR 1.3 (95% CI: 0.4–4.4). Terbinafine was marginally more efficacious than itraconazole, RR 1.3 (95% CI: 1.1–1.5). Summary/Conclusion: Topical terbinafine and butenafine treatments of tinea pedis were more efficacious than placebo. Tableted terbinafine and itraconazole administered orally were efficacious in the drug treatment of tinea pedis fungal infection. We are concerned about how few studies were available that reported the baseline characteristics for each treatment arm and that did not suffer greater than 20% loss to follow-up. We would like to see improved reporting of clinical trials in academic literature. Registration name: Treatment’s for athlete’s foot—systematic review with meta-analysis [CRD42020162078].https://www.mdpi.com/2309-608X/8/4/351tinea pedisathlete’s foottreatment |
| spellingShingle | Harry Ward Nicholas Parkes Carolyn Smith Stefan Kluzek Richard Pearson Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials Journal of Fungi tinea pedis athlete’s foot treatment |
| title | Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials |
| title_full | Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials |
| title_fullStr | Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials |
| title_full_unstemmed | Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials |
| title_short | Consensus for the Treatment of Tinea Pedis: A Systematic Review of Randomised Controlled Trials |
| title_sort | consensus for the treatment of tinea pedis a systematic review of randomised controlled trials |
| topic | tinea pedis athlete’s foot treatment |
| url | https://www.mdpi.com/2309-608X/8/4/351 |
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