Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection
Concurrent hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is not uncommon as the two viruses shared the similar transmission routes. HCV is usually the dominant virus to suppress HBV, and HBV reactivation may occur during or after the course of anti-HCV treatment. By contrast, HCV rea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1136111/full |
| _version_ | 1797924665753075712 |
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| author | Yi-Tse Su Yi-Tse Su Ming-Ling Chang Ming-Ling Chang Yun-Fan Liaw Yun-Fan Liaw |
| author_facet | Yi-Tse Su Yi-Tse Su Ming-Ling Chang Ming-Ling Chang Yun-Fan Liaw Yun-Fan Liaw |
| author_sort | Yi-Tse Su |
| collection | DOAJ |
| description | Concurrent hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is not uncommon as the two viruses shared the similar transmission routes. HCV is usually the dominant virus to suppress HBV, and HBV reactivation may occur during or after the course of anti-HCV treatment. By contrast, HCV reactivation after anti-HBV therapy in the concurrent HBV- and HCV-infected patients was rarely noted. Here, we reported the unusual viral evolutions of a patient with concurrent HBV and HCV infection, in whom HCV reactivation occurred during the entecavir therapy to rescue the severe HBV flare, while the following anti-HCV combination therapy with pegylated interferon and ribavirin elicited the second HBV flare despite sustained virological response to HCV infection, and further entecavir therapy healed the flare. |
| first_indexed | 2024-04-10T15:04:30Z |
| format | Article |
| id | doaj.art-b9ca00cef4f4422b874b64d9cd127ee5 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T15:04:30Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-b9ca00cef4f4422b874b64d9cd127ee52023-02-15T07:05:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-011010.3389/fmed.2023.11361111136111Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infectionYi-Tse Su0Yi-Tse Su1Ming-Ling Chang2Ming-Ling Chang3Yun-Fan Liaw4Yun-Fan Liaw5Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan, TaiwanLiver Research Unit, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan, TaiwanLiver Research Unit, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan, TaiwanConcurrent hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is not uncommon as the two viruses shared the similar transmission routes. HCV is usually the dominant virus to suppress HBV, and HBV reactivation may occur during or after the course of anti-HCV treatment. By contrast, HCV reactivation after anti-HBV therapy in the concurrent HBV- and HCV-infected patients was rarely noted. Here, we reported the unusual viral evolutions of a patient with concurrent HBV and HCV infection, in whom HCV reactivation occurred during the entecavir therapy to rescue the severe HBV flare, while the following anti-HCV combination therapy with pegylated interferon and ribavirin elicited the second HBV flare despite sustained virological response to HCV infection, and further entecavir therapy healed the flare.https://www.frontiersin.org/articles/10.3389/fmed.2023.1136111/fullchronic hepatitis Bchronic hepatitis Cco-infectionreactivationentecavir |
| spellingShingle | Yi-Tse Su Yi-Tse Su Ming-Ling Chang Ming-Ling Chang Yun-Fan Liaw Yun-Fan Liaw Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection Frontiers in Medicine chronic hepatitis B chronic hepatitis C co-infection reactivation entecavir |
| title | Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection |
| title_full | Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection |
| title_fullStr | Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection |
| title_full_unstemmed | Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection |
| title_short | Case report: Unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis B virus and hepatitis C virus infection |
| title_sort | case report unusual viral evolutions following antiviral therapies in a patient with concurrent hepatitis b virus and hepatitis c virus infection |
| topic | chronic hepatitis B chronic hepatitis C co-infection reactivation entecavir |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1136111/full |
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