Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand
Two new triterpenoid glucosides, Heritiera A (<b>1</b>) and Heritiera B (<b>2</b>), and six known triterpenoid analogs (<b>3</b>–<b>8</b>) were isolated from <i>Heritiera littoralis</i> Dryand. Their structures were identified by comprehens...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/4/1658 |
| Summary: | Two new triterpenoid glucosides, Heritiera A (<b>1</b>) and Heritiera B (<b>2</b>), and six known triterpenoid analogs (<b>3</b>–<b>8</b>) were isolated from <i>Heritiera littoralis</i> Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from <i>H. littoralis</i> was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound <b>2</b> substantially inhibits the release of nitric oxide (NO) with an IC<sub>50</sub> value of 10.33 μM. The triterpenoids from <i>H. littoralis</i> could be used as potential candidates for the development of new anti-inflammatory agents. |
|---|---|
| ISSN: | 1420-3049 |