Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand
Two new triterpenoid glucosides, Heritiera A (<b>1</b>) and Heritiera B (<b>2</b>), and six known triterpenoid analogs (<b>3</b>–<b>8</b>) were isolated from <i>Heritiera littoralis</i> Dryand. Their structures were identified by comprehens...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/4/1658 |
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| author | Xiaoqin Liang Peng Niu Jun Li Xinlan Guan Yanjun Zhang Jian Li |
| author_facet | Xiaoqin Liang Peng Niu Jun Li Xinlan Guan Yanjun Zhang Jian Li |
| author_sort | Xiaoqin Liang |
| collection | DOAJ |
| description | Two new triterpenoid glucosides, Heritiera A (<b>1</b>) and Heritiera B (<b>2</b>), and six known triterpenoid analogs (<b>3</b>–<b>8</b>) were isolated from <i>Heritiera littoralis</i> Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from <i>H. littoralis</i> was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound <b>2</b> substantially inhibits the release of nitric oxide (NO) with an IC<sub>50</sub> value of 10.33 μM. The triterpenoids from <i>H. littoralis</i> could be used as potential candidates for the development of new anti-inflammatory agents. |
| first_indexed | 2024-03-11T08:22:31Z |
| format | Article |
| id | doaj.art-b9ca3037b21342fb9f30c3376932b63d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T08:22:31Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b9ca3037b21342fb9f30c3376932b63d2023-11-16T22:21:32ZengMDPI AGMolecules1420-30492023-02-01284165810.3390/molecules28041658Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> DryandXiaoqin Liang0Peng Niu1Jun Li2Xinlan Guan3Yanjun Zhang4Jian Li5Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, ChinaGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, ChinaState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemical & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaPeoples’ Hospital of Pubei, Qinzhou 535300, ChinaGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, ChinaPeoples’ Hospital of Pubei, Qinzhou 535300, ChinaTwo new triterpenoid glucosides, Heritiera A (<b>1</b>) and Heritiera B (<b>2</b>), and six known triterpenoid analogs (<b>3</b>–<b>8</b>) were isolated from <i>Heritiera littoralis</i> Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from <i>H. littoralis</i> was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound <b>2</b> substantially inhibits the release of nitric oxide (NO) with an IC<sub>50</sub> value of 10.33 μM. The triterpenoids from <i>H. littoralis</i> could be used as potential candidates for the development of new anti-inflammatory agents.https://www.mdpi.com/1420-3049/28/4/1658<i>Heritiera littoralis</i> Dryand.Heritiera AHeritiera Banti-inflammatory |
| spellingShingle | Xiaoqin Liang Peng Niu Jun Li Xinlan Guan Yanjun Zhang Jian Li Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand Molecules <i>Heritiera littoralis</i> Dryand. Heritiera A Heritiera B anti-inflammatory |
| title | Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand |
| title_full | Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand |
| title_fullStr | Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand |
| title_full_unstemmed | Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand |
| title_short | Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand |
| title_sort | discovery of anti inflammatory triterpenoid glucosides from the i heritiera littoralis i dryand |
| topic | <i>Heritiera littoralis</i> Dryand. Heritiera A Heritiera B anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/28/4/1658 |
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