First-in-human trial of a novel suprachoroidal retinal prosthesis.
Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical app...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4270734?pdf=render |
| _version_ | 1819086602170793984 |
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| author | Lauren N Ayton Peter J Blamey Robyn H Guymer Chi D Luu David A X Nayagam Nicholas C Sinclair Mohit N Shivdasani Jonathan Yeoh Mark F McCombe Robert J Briggs Nicholas L Opie Joel Villalobos Peter N Dimitrov Mary Varsamidis Matthew A Petoe Chris D McCarthy Janine G Walker Nick Barnes Anthony N Burkitt Chris E Williams Robert K Shepherd Penelope J Allen Bionic Vision Australia Research Consortium |
| author_facet | Lauren N Ayton Peter J Blamey Robyn H Guymer Chi D Luu David A X Nayagam Nicholas C Sinclair Mohit N Shivdasani Jonathan Yeoh Mark F McCombe Robert J Briggs Nicholas L Opie Joel Villalobos Peter N Dimitrov Mary Varsamidis Matthew A Petoe Chris D McCarthy Janine G Walker Nick Barnes Anthony N Burkitt Chris E Williams Robert K Shepherd Penelope J Allen Bionic Vision Australia Research Consortium |
| author_sort | Lauren N Ayton |
| collection | DOAJ |
| description | Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration.Clinicaltrials.gov NCT01603576. |
| first_indexed | 2024-12-21T21:22:51Z |
| format | Article |
| id | doaj.art-b9cb3c37192546c5b6a4c81a3d6f7157 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T21:22:51Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b9cb3c37192546c5b6a4c81a3d6f71572022-12-21T18:49:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11523910.1371/journal.pone.0115239First-in-human trial of a novel suprachoroidal retinal prosthesis.Lauren N AytonPeter J BlameyRobyn H GuymerChi D LuuDavid A X NayagamNicholas C SinclairMohit N ShivdasaniJonathan YeohMark F McCombeRobert J BriggsNicholas L OpieJoel VillalobosPeter N DimitrovMary VarsamidisMatthew A PetoeChris D McCarthyJanine G WalkerNick BarnesAnthony N BurkittChris E WilliamsRobert K ShepherdPenelope J AllenBionic Vision Australia Research ConsortiumRetinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration.Clinicaltrials.gov NCT01603576.http://europepmc.org/articles/PMC4270734?pdf=render |
| spellingShingle | Lauren N Ayton Peter J Blamey Robyn H Guymer Chi D Luu David A X Nayagam Nicholas C Sinclair Mohit N Shivdasani Jonathan Yeoh Mark F McCombe Robert J Briggs Nicholas L Opie Joel Villalobos Peter N Dimitrov Mary Varsamidis Matthew A Petoe Chris D McCarthy Janine G Walker Nick Barnes Anthony N Burkitt Chris E Williams Robert K Shepherd Penelope J Allen Bionic Vision Australia Research Consortium First-in-human trial of a novel suprachoroidal retinal prosthesis. PLoS ONE |
| title | First-in-human trial of a novel suprachoroidal retinal prosthesis. |
| title_full | First-in-human trial of a novel suprachoroidal retinal prosthesis. |
| title_fullStr | First-in-human trial of a novel suprachoroidal retinal prosthesis. |
| title_full_unstemmed | First-in-human trial of a novel suprachoroidal retinal prosthesis. |
| title_short | First-in-human trial of a novel suprachoroidal retinal prosthesis. |
| title_sort | first in human trial of a novel suprachoroidal retinal prosthesis |
| url | http://europepmc.org/articles/PMC4270734?pdf=render |
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