Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients
Primary membrane nephropathy (PMN) and IgA nephropathy (IgAN) are the most common glomerular diseases in China. Because of different pathogenesis, prognosis is significantly different. When the two diseases coexist (PMN/IgAN), the clinicopathological manifestations and prognosis remain unclear. In t...
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MDPI AG
2022-12-01
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| author | Wenrong Cheng Guoqin Wang Weiyi Guo Lijun Sun Xiaoyi Xu Hongrui Dong Suhua Ye Yanqiu Geng Hong Cheng |
| author_facet | Wenrong Cheng Guoqin Wang Weiyi Guo Lijun Sun Xiaoyi Xu Hongrui Dong Suhua Ye Yanqiu Geng Hong Cheng |
| author_sort | Wenrong Cheng |
| collection | DOAJ |
| description | Primary membrane nephropathy (PMN) and IgA nephropathy (IgAN) are the most common glomerular diseases in China. Because of different pathogenesis, prognosis is significantly different. When the two diseases coexist (PMN/IgAN), the clinicopathological manifestations and prognosis remain unclear. In the present study, we analyzed the clinicopathological characteristics of PMN/IgAN patients, with only IgA deposition (PMN/IgA deposition) patients as controls. Galactose-deficient IgA1(KM55) and M-type Phospholipase A2 Receptor(PLA2R), both in circulation and renal tissues, were detected. Furthermore, prognosis of PMN/IgAN was explored. We found that PMN/IgAN also had some clinical features of IgAN in addition to PMN, such as higher serum albumin, along with a similar heavy proteinuria and lower titers of serum anti-PLA2R antibody. The positive rate of glomerular KM55 in PMN/IgAN was 23.5% (20/85), and 0% (0/29) in PMN/IgA deposition. Among those glomerular KM55 positive patients, KM55 and IgA colocalized mainly along the glomerular mesangial and capillary areas. Unfortunately, there was no significant difference in serum level of Gd-IgA1 between KM55+ and KM55− subgroups in PMN/IgAN patients, similar to the PMN/IgA deposition group. Notably, glomerular KM55 positive may predict a poorer prognosis in PMN/IgAN patients. In conclusion, our study suggested that, when glomerular KM55 staining was positive, this special coexisting PMN/IgAN disorder was prone to have more characteristics of IgAN besides PMN, and may predict poorer prognosis, while the mechanism requires further investigation. |
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| spelling | doaj.art-b9ce05507aa3496e97a7f3ce5c68d7942023-11-16T15:06:18ZengMDPI AGCells2073-44092022-12-0112111610.3390/cells12010116Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy PatientsWenrong Cheng0Guoqin Wang1Weiyi Guo2Lijun Sun3Xiaoyi Xu4Hongrui Dong5Suhua Ye6Yanqiu Geng7Hong Cheng8Renal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaDivision of Nephrology, Affiliated Hospital of Chifeng University, Neimenggu 024000, ChinaDivision of Nephrology, The Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaRenal Division, Department of Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaPrimary membrane nephropathy (PMN) and IgA nephropathy (IgAN) are the most common glomerular diseases in China. Because of different pathogenesis, prognosis is significantly different. When the two diseases coexist (PMN/IgAN), the clinicopathological manifestations and prognosis remain unclear. In the present study, we analyzed the clinicopathological characteristics of PMN/IgAN patients, with only IgA deposition (PMN/IgA deposition) patients as controls. Galactose-deficient IgA1(KM55) and M-type Phospholipase A2 Receptor(PLA2R), both in circulation and renal tissues, were detected. Furthermore, prognosis of PMN/IgAN was explored. We found that PMN/IgAN also had some clinical features of IgAN in addition to PMN, such as higher serum albumin, along with a similar heavy proteinuria and lower titers of serum anti-PLA2R antibody. The positive rate of glomerular KM55 in PMN/IgAN was 23.5% (20/85), and 0% (0/29) in PMN/IgA deposition. Among those glomerular KM55 positive patients, KM55 and IgA colocalized mainly along the glomerular mesangial and capillary areas. Unfortunately, there was no significant difference in serum level of Gd-IgA1 between KM55+ and KM55− subgroups in PMN/IgAN patients, similar to the PMN/IgA deposition group. Notably, glomerular KM55 positive may predict a poorer prognosis in PMN/IgAN patients. In conclusion, our study suggested that, when glomerular KM55 staining was positive, this special coexisting PMN/IgAN disorder was prone to have more characteristics of IgAN besides PMN, and may predict poorer prognosis, while the mechanism requires further investigation.https://www.mdpi.com/2073-4409/12/1/116galactose-deficient IgA1KM55primary membranous nephropathyIgA nephropathyIgA depositionprognosis |
| spellingShingle | Wenrong Cheng Guoqin Wang Weiyi Guo Lijun Sun Xiaoyi Xu Hongrui Dong Suhua Ye Yanqiu Geng Hong Cheng Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients Cells galactose-deficient IgA1 KM55 primary membranous nephropathy IgA nephropathy IgA deposition prognosis |
| title | Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients |
| title_full | Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients |
| title_fullStr | Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients |
| title_full_unstemmed | Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients |
| title_short | Glomerular Galactose-Deficient IgA1(KM55) Positive May Predict Poorer Prognosis in Coexisting Primary Membranous Nephropathy and IgA Nephropathy Patients |
| title_sort | glomerular galactose deficient iga1 km55 positive may predict poorer prognosis in coexisting primary membranous nephropathy and iga nephropathy patients |
| topic | galactose-deficient IgA1 KM55 primary membranous nephropathy IgA nephropathy IgA deposition prognosis |
| url | https://www.mdpi.com/2073-4409/12/1/116 |
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