The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231723001271 |
| _version_ | 1827934029143343104 |
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| author | Simone Adinolfi Tommi Patinen Ashik Jawahar Deen Sini Pitkänen Jouni Härkönen Emilia Kansanen Jenni Küblbeck Anna-Liisa Levonen |
| author_facet | Simone Adinolfi Tommi Patinen Ashik Jawahar Deen Sini Pitkänen Jouni Härkönen Emilia Kansanen Jenni Küblbeck Anna-Liisa Levonen |
| author_sort | Simone Adinolfi |
| collection | DOAJ |
| description | The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of NRF2 signaling and its downstream effects to identify novel targets for therapy. In this graphical review, we present an updated overview of the KEAP1-NRF2 signaling, focusing on the progress made within the past ten years. Specifically, we highlight the advances made in understanding the mechanism of activation of NRF2, resulting in novel discoveries in its therapeutic targeting. Furthermore, we will summarize new findings in the rapidly expanding field of NRF2 in cancer, with important implications for its diagnostics and treatment. |
| first_indexed | 2024-03-13T07:32:49Z |
| format | Article |
| id | doaj.art-b9ce4d24942d4266829fce396e5ff767 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-03-13T07:32:49Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-b9ce4d24942d4266829fce396e5ff7672023-06-04T04:23:45ZengElsevierRedox Biology2213-23172023-07-0163102726The KEAP1-NRF2 pathway: Targets for therapy and role in cancerSimone Adinolfi0Tommi Patinen1Ashik Jawahar Deen2Sini Pitkänen3Jouni Härkönen4Emilia Kansanen5Jenni Küblbeck6Anna-Liisa Levonen7A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, Finland; Department of Pathology, Hospital Nova of Central Finland, Jyväskylä, 40620, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, Finland; Science Service Center, Kuopio University Hospital, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210, Kuopio, Finland; Corresponding author. University of Eastern Finland, A.I.Virtanen Institute for Molecular Sciences, P.O.Box 1627, 70211 Kuopio, Finland.The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of NRF2 signaling and its downstream effects to identify novel targets for therapy. In this graphical review, we present an updated overview of the KEAP1-NRF2 signaling, focusing on the progress made within the past ten years. Specifically, we highlight the advances made in understanding the mechanism of activation of NRF2, resulting in novel discoveries in its therapeutic targeting. Furthermore, we will summarize new findings in the rapidly expanding field of NRF2 in cancer, with important implications for its diagnostics and treatment.http://www.sciencedirect.com/science/article/pii/S2213231723001271NRF2KEAP1CancerGene regulation |
| spellingShingle | Simone Adinolfi Tommi Patinen Ashik Jawahar Deen Sini Pitkänen Jouni Härkönen Emilia Kansanen Jenni Küblbeck Anna-Liisa Levonen The KEAP1-NRF2 pathway: Targets for therapy and role in cancer Redox Biology NRF2 KEAP1 Cancer Gene regulation |
| title | The KEAP1-NRF2 pathway: Targets for therapy and role in cancer |
| title_full | The KEAP1-NRF2 pathway: Targets for therapy and role in cancer |
| title_fullStr | The KEAP1-NRF2 pathway: Targets for therapy and role in cancer |
| title_full_unstemmed | The KEAP1-NRF2 pathway: Targets for therapy and role in cancer |
| title_short | The KEAP1-NRF2 pathway: Targets for therapy and role in cancer |
| title_sort | keap1 nrf2 pathway targets for therapy and role in cancer |
| topic | NRF2 KEAP1 Cancer Gene regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2213231723001271 |
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