The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of...

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Bibliographic Details
Main Authors: Simone Adinolfi, Tommi Patinen, Ashik Jawahar Deen, Sini Pitkänen, Jouni Härkönen, Emilia Kansanen, Jenni Küblbeck, Anna-Liisa Levonen
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
Subjects:
NRF2
KEAP1
Cancer
Gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001271

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