FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Cell Adhesion & Migration |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336918.2020.1766308 |
| _version_ | 1818964564133281792 |
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| author | Ying Yang Tingting Lu Ziming Li Shun Lu |
| author_facet | Ying Yang Tingting Lu Ziming Li Shun Lu |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines. Significance: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits. |
| first_indexed | 2024-12-20T13:03:07Z |
| format | Article |
| id | doaj.art-b9cf07f1058d4ce8a81e6088f1203bc4 |
| institution | Directory Open Access Journal |
| issn | 1933-6918 1933-6926 |
| language | English |
| last_indexed | 2024-12-20T13:03:07Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj.art-b9cf07f1058d4ce8a81e6088f1203bc42022-12-21T19:39:52ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262020-01-01141829510.1080/19336918.2020.17663081766308FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancerYing Yang0Tingting Lu1Ziming Li2Shun Lu3Shanghai Chest Hospital, Shanghai Jiao Tong UniversityShanghai Chest Hospital, Shanghai Jiao Tong UniversityShanghai Chest Hospital, Shanghai Jiao Tong UniversityShanghai Chest Hospital, Shanghai Jiao Tong UniversityAims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines. Significance: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits.http://dx.doi.org/10.1080/19336918.2020.1766308ccnd1fgfr1co-ipepithelial-mesenchymal transitionlung cancer |
| spellingShingle | Ying Yang Tingting Lu Ziming Li Shun Lu FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer Cell Adhesion & Migration ccnd1 fgfr1 co-ip epithelial-mesenchymal transition lung cancer |
| title | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
| title_full | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
| title_fullStr | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
| title_full_unstemmed | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
| title_short | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
| title_sort | fgfr1 regulates proliferation and metastasis by targeting ccnd1 in fgfr1 amplified lung cancer |
| topic | ccnd1 fgfr1 co-ip epithelial-mesenchymal transition lung cancer |
| url | http://dx.doi.org/10.1080/19336918.2020.1766308 |
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