Ameloblastic fibrosarcoma – A rarity?
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour classified by the WHO (1992) as an odontogenic sarcoma and defined as “a neoplasm with a similar structure to ameloblastic fibroma (AF) but in which the ectomesenchymal component shows the features of a sarcoma.” The first report...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | JPRAS Open |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352587819300221 |
| _version_ | 1819014758667386880 |
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| author | M.S. Munisekhar Sanjeevareddigari Shylaja R. Vijay Kumar Krishna A. Rao Santosh R. Patil Mohammad Khursheed Alam |
| author_facet | M.S. Munisekhar Sanjeevareddigari Shylaja R. Vijay Kumar Krishna A. Rao Santosh R. Patil Mohammad Khursheed Alam |
| author_sort | M.S. Munisekhar |
| collection | DOAJ |
| description | Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour classified by the WHO (1992) as an odontogenic sarcoma and defined as “a neoplasm with a similar structure to ameloblastic fibroma (AF) but in which the ectomesenchymal component shows the features of a sarcoma.” The first report of AFS was published by Heath in 1887. AFS and related lesions are less frequently diagnosed than odontogenic carcinomas. Approximately two-thirds of AFSs seem to arise de novo, but others have developed in recurrent AF, in which the ectomesenchymal cells retain their embryonic appearance and develop malignant characteristics. We report a rare case of an aggressive odontogenic neoplasm, the incisional biopsy of which showed the features of AF, while the excisional biopsy revealed the features of malignancy, suggestive of AFS.The purpose of this report is to discuss the diagnostic difficulties, whether AFS is truly an extremely rare tumour as reported earlier and, lastly, should the treatment protocols of AFs be revised, as 44% of AFSs arise from recurrent AFs. Keywords: Odontogenic fibrosarcoma, Odontogenic sarcoma, Ameloblastic fibrosarcoma, Ameloblastic fibroma |
| first_indexed | 2024-12-21T02:20:56Z |
| format | Article |
| id | doaj.art-b9d2e02e774449e3b64df7df9fdc17b8 |
| institution | Directory Open Access Journal |
| issn | 2352-5878 |
| language | English |
| last_indexed | 2024-12-21T02:20:56Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JPRAS Open |
| spelling | doaj.art-b9d2e02e774449e3b64df7df9fdc17b82022-12-21T19:19:08ZengElsevierJPRAS Open2352-58782019-09-01215662Ameloblastic fibrosarcoma – A rarity?M.S. Munisekhar0Sanjeevareddigari Shylaja1R. Vijay Kumar2Krishna A. Rao3Santosh R. Patil4Mohammad Khursheed Alam5Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia; Corresponding author.Department of Oral Pathology, SVS Institute of Dental Sciences, Mahabubnagar, IndiaDepartment of Oral and Maxillofacial Surgery, SVS Institute of Dental Sciences, Mahabubnagar, IndiaDepartment of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi ArabiaDepartment of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Chennai, IndiaDepartment of Orthodontics, College of Dentistry, Jouf University, Kingdom of Saudi ArabiaAmeloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour classified by the WHO (1992) as an odontogenic sarcoma and defined as “a neoplasm with a similar structure to ameloblastic fibroma (AF) but in which the ectomesenchymal component shows the features of a sarcoma.” The first report of AFS was published by Heath in 1887. AFS and related lesions are less frequently diagnosed than odontogenic carcinomas. Approximately two-thirds of AFSs seem to arise de novo, but others have developed in recurrent AF, in which the ectomesenchymal cells retain their embryonic appearance and develop malignant characteristics. We report a rare case of an aggressive odontogenic neoplasm, the incisional biopsy of which showed the features of AF, while the excisional biopsy revealed the features of malignancy, suggestive of AFS.The purpose of this report is to discuss the diagnostic difficulties, whether AFS is truly an extremely rare tumour as reported earlier and, lastly, should the treatment protocols of AFs be revised, as 44% of AFSs arise from recurrent AFs. Keywords: Odontogenic fibrosarcoma, Odontogenic sarcoma, Ameloblastic fibrosarcoma, Ameloblastic fibromahttp://www.sciencedirect.com/science/article/pii/S2352587819300221 |
| spellingShingle | M.S. Munisekhar Sanjeevareddigari Shylaja R. Vijay Kumar Krishna A. Rao Santosh R. Patil Mohammad Khursheed Alam Ameloblastic fibrosarcoma – A rarity? JPRAS Open |
| title | Ameloblastic fibrosarcoma – A rarity? |
| title_full | Ameloblastic fibrosarcoma – A rarity? |
| title_fullStr | Ameloblastic fibrosarcoma – A rarity? |
| title_full_unstemmed | Ameloblastic fibrosarcoma – A rarity? |
| title_short | Ameloblastic fibrosarcoma – A rarity? |
| title_sort | ameloblastic fibrosarcoma a rarity |
| url | http://www.sciencedirect.com/science/article/pii/S2352587819300221 |
| work_keys_str_mv | AT msmunisekhar ameloblasticfibrosarcomaararity AT sanjeevareddigarishylaja ameloblasticfibrosarcomaararity AT rvijaykumar ameloblasticfibrosarcomaararity AT krishnaarao ameloblasticfibrosarcomaararity AT santoshrpatil ameloblasticfibrosarcomaararity AT mohammadkhursheedalam ameloblasticfibrosarcomaararity |