Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases
Patients with advanced colorectal cancer (CRC) with distant metastases have a poor prognosis. We evaluated the clinicopathological relevance of GRP94 expression in these cases. The immunohistochemical expression of GRP94 was studied in 189 CRC patients with synchronous (SM; <i>n</i> = 12...
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/7042 |
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| author | Sumi Yun Sukmook Lee Ho-Young Lee Hyeon Jeong Oh Yoonjin Kwak Hye Seung Lee |
| author_facet | Sumi Yun Sukmook Lee Ho-Young Lee Hyeon Jeong Oh Yoonjin Kwak Hye Seung Lee |
| author_sort | Sumi Yun |
| collection | DOAJ |
| description | Patients with advanced colorectal cancer (CRC) with distant metastases have a poor prognosis. We evaluated the clinicopathological relevance of GRP94 expression in these cases. The immunohistochemical expression of GRP94 was studied in 189 CRC patients with synchronous (SM; <i>n</i> = 123) and metachronous metastases (MM; <i>n</i> = 66), using tissue microarray; the association between GRP94 expression, outcome, and tumor-infiltrating lymphocytes (TILs) was also evaluated. GRP94 was expressed in 64.6% (122/189) patients with CRC; GRP94 positivity was found in 67.5% and 59.1% patients with SM and MM, respectively. In the SM group, high GRP94 expression was more common in patients with a higher density of CD4+ TILs (<i>p</i> = 0.002), unlike in the MM group. Survival analysis showed that patients with GRP94 positivity had significantly favorable survival (<i>p</i> = 0.030); after multivariate analysis, GRP94 only served as an independent prognostic factor (<i>p</i> = 0.034; hazard ratio, 0.581; 95% confidence interval, 0.351–0.961) in the SM group. GRP94 expression was detected in 49.4% of metastatic sites and showed significant heterogeneity between primary and metastatic lesions (<i>p</i> = 0.012). GRP94 is widely expressed in CRC with distant metastases; its expression was associated with favorable prognosis in the SM group, unlike in the MM group. |
| first_indexed | 2024-03-10T09:56:04Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:56:04Z |
| publishDate | 2021-06-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b9d30ae85adf444598fd7f38bf4398052023-11-22T02:19:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213704210.3390/ijms22137042Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous MetastasesSumi Yun0Sukmook Lee1Ho-Young Lee2Hyeon Jeong Oh3Yoonjin Kwak4Hye Seung Lee5Samkwang Medical Laboratories, Department of Diagnostic Pathology, Seoul 06742, KoreaBiopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, KoreaDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, KoreaDepartment of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, KoreaDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaPatients with advanced colorectal cancer (CRC) with distant metastases have a poor prognosis. We evaluated the clinicopathological relevance of GRP94 expression in these cases. The immunohistochemical expression of GRP94 was studied in 189 CRC patients with synchronous (SM; <i>n</i> = 123) and metachronous metastases (MM; <i>n</i> = 66), using tissue microarray; the association between GRP94 expression, outcome, and tumor-infiltrating lymphocytes (TILs) was also evaluated. GRP94 was expressed in 64.6% (122/189) patients with CRC; GRP94 positivity was found in 67.5% and 59.1% patients with SM and MM, respectively. In the SM group, high GRP94 expression was more common in patients with a higher density of CD4+ TILs (<i>p</i> = 0.002), unlike in the MM group. Survival analysis showed that patients with GRP94 positivity had significantly favorable survival (<i>p</i> = 0.030); after multivariate analysis, GRP94 only served as an independent prognostic factor (<i>p</i> = 0.034; hazard ratio, 0.581; 95% confidence interval, 0.351–0.961) in the SM group. GRP94 expression was detected in 49.4% of metastatic sites and showed significant heterogeneity between primary and metastatic lesions (<i>p</i> = 0.012). GRP94 is widely expressed in CRC with distant metastases; its expression was associated with favorable prognosis in the SM group, unlike in the MM group.https://www.mdpi.com/1422-0067/22/13/7042GRP94tumor-infiltrating lymphocytecolorectal cancerprognosis |
| spellingShingle | Sumi Yun Sukmook Lee Ho-Young Lee Hyeon Jeong Oh Yoonjin Kwak Hye Seung Lee Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases International Journal of Molecular Sciences GRP94 tumor-infiltrating lymphocyte colorectal cancer prognosis |
| title | Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases |
| title_full | Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases |
| title_fullStr | Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases |
| title_full_unstemmed | Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases |
| title_short | Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases |
| title_sort | clinicopathologic and prognostic association of grp94 expression in colorectal cancer with synchronous and metachronous metastases |
| topic | GRP94 tumor-infiltrating lymphocyte colorectal cancer prognosis |
| url | https://www.mdpi.com/1422-0067/22/13/7042 |
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