Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography
Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA). Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified...
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| Format: | Article |
| Language: | English |
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Knowledge E
2018-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2018;volume=13;issue=4;spage=426;epage=432;aulast=El |
| _version_ | 1828217773911703552 |
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| author | Ala'a El Ameen Carl P Herbort Jr |
| author_facet | Ala'a El Ameen Carl P Herbort Jr |
| author_sort | Ala'a El Ameen |
| collection | DOAJ |
| description | Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA).
Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis.
Results: The choroid was predominantly involved in 19 (82.6%) patients or 87% (40/46) of the eyes, and the retina in 2 (8.7%) patients or 13% (6/46) of the eyes. The mean angiographic score was 7.15 ± 4.5 for the retina (FA) compared to 14.02 ± 4.86 for the choroid (ICGA) (P < 0.0001). In 13% (3/23) of patients, FA did not show retinal inflammation, whereas ICGA was strongly positive, revealing occult choroidal lesions.
Conclusion: The choroid is preferentially involved in OS, for which ICGA is the examination of choice. There is a risk of underestimating the global ocular involvement and of missing choroidal involvement if only FA is used. FA/ICGA scoring system allows for quantitative assessment of inflammation in the posterior uvea that occurs in OS; therefore, the system can be useful to quantitatively monitor outcomes in clinical trials. |
| first_indexed | 2024-04-12T15:53:09Z |
| format | Article |
| id | doaj.art-b9d4700643ae456093ab5ed7816fb96a |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-12T15:53:09Z |
| publishDate | 2018-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-b9d4700643ae456093ab5ed7816fb96a2022-12-22T03:26:27ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2018-01-0113442643210.4103/jovr.jovr_201_17Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiographyAla'a El AmeenCarl P Herbort JrPurpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA). Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis. Results: The choroid was predominantly involved in 19 (82.6%) patients or 87% (40/46) of the eyes, and the retina in 2 (8.7%) patients or 13% (6/46) of the eyes. The mean angiographic score was 7.15 ± 4.5 for the retina (FA) compared to 14.02 ± 4.86 for the choroid (ICGA) (P < 0.0001). In 13% (3/23) of patients, FA did not show retinal inflammation, whereas ICGA was strongly positive, revealing occult choroidal lesions. Conclusion: The choroid is preferentially involved in OS, for which ICGA is the examination of choice. There is a risk of underestimating the global ocular involvement and of missing choroidal involvement if only FA is used. FA/ICGA scoring system allows for quantitative assessment of inflammation in the posterior uvea that occurs in OS; therefore, the system can be useful to quantitatively monitor outcomes in clinical trials.http://www.jovr.org/article.asp?issn=2008-322X;year=2018;volume=13;issue=4;spage=426;epage=432;aulast=ElAngiographic Score; Chorioretinitis; Fluorescein Angiography; Indocyanine Green Angiography; Ocular Sarcoidosis |
| spellingShingle | Ala'a El Ameen Carl P Herbort Jr Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography Journal of Ophthalmic & Vision Research Angiographic Score; Chorioretinitis; Fluorescein Angiography; Indocyanine Green Angiography; Ocular Sarcoidosis |
| title | Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography |
| title_full | Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography |
| title_fullStr | Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography |
| title_full_unstemmed | Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography |
| title_short | Comparison of retinal and choroidal involvement in sarcoidosis-related chorioretinitis using fluorescein and indocyanine green angiography |
| title_sort | comparison of retinal and choroidal involvement in sarcoidosis related chorioretinitis using fluorescein and indocyanine green angiography |
| topic | Angiographic Score; Chorioretinitis; Fluorescein Angiography; Indocyanine Green Angiography; Ocular Sarcoidosis |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2018;volume=13;issue=4;spage=426;epage=432;aulast=El |
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