FBXO22 degrades nuclear PTEN to promote tumorigenesis
Loss of nuclear PTEN is associated with aggressive cancers. Here the authors show that nuclear PTEN is more susceptible to ubiquitin-mediated proteasomal degradation than cytoplasmic PTEN, and identify FBXO22 ubiquitinates and degrades nuclear PTEN to promote tumorigenesis.
Bibliographic Details
| Main Authors: |
Meng-Kai Ge,
Na Zhang,
Li Xia,
Cheng Zhang,
Shuang-Shu Dong,
Zhan-Ming Li,
Yan Ji,
Min-Hua Zheng,
Jing Sun,
Guo-Qiang Chen,
Shao-Ming Shen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15578-1
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