Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles
The prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans. The generalized linear model (GLM) was used to analyze the associations between seminal prosaposin concentrations and normal...
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| Format: | Article |
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PeerJ Inc.
2019-12-01
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| Online Access: | https://peerj.com/articles/8177.pdf |
| _version_ | 1797420215079796736 |
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| author | Chun Xu Jiali Cai Lanlan Liu Jianzhi Ren |
| author_facet | Chun Xu Jiali Cai Lanlan Liu Jianzhi Ren |
| author_sort | Chun Xu |
| collection | DOAJ |
| description | The prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans. The generalized linear model (GLM) was used to analyze the associations between seminal prosaposin concentrations and normal fertilization rates and good embryos proportion. The generalized estimating equation (GEE) was used to evaluate the association between embryo parameters and the prosaposin concentrations. Each model was adjusted for age of the couples, female basal FSH, AFC and BMI, starting dose and oocyte yield of IVF cycles and smoker. GLM models suggested that prosaposin was significantly associated with fertilization rate (P = 0.005) and good embryo proportion (P = 0.038) while none of the semen parameters (sperm concentration, motility, progressive motility, normal morphology rate, postwash sperm concentration and motility) was significantly associated with the parameters in the cohort. Using GEE, it was also shown that prosaposin was positively associated with the occurrence of early cleavage and negatively associated with uneven cleavage pattern on day 3. In both the overall population and the normozoospermia patients, the prosaposin was significantly associated with pregnancy with adjustment with covariates. In conclusion, our data suggested that seminal prosaposin concentration could provide more information regarding normal fertilization and embryo development in IVF than traditional semen parameters. |
| first_indexed | 2024-03-09T06:59:26Z |
| format | Article |
| id | doaj.art-b9d595c379724746b628ac3e3582458d |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:59:26Z |
| publishDate | 2019-12-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-b9d595c379724746b628ac3e3582458d2023-12-03T09:57:01ZengPeerJ Inc.PeerJ2167-83592019-12-017e817710.7717/peerj.8177Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cyclesChun Xu0Jiali Cai1Lanlan Liu2Jianzhi Ren3Reproductive Medicine Centre, Chinese PLA 174th Hospital, Xiamen, Fujian, ChinaReproductive Medicine Centre, Chinese PLA 174th Hospital, Xiamen, Fujian, ChinaReproductive Medicine Centre, Chinese PLA 174th Hospital, Xiamen, Fujian, ChinaReproductive Medicine Centre, Chinese PLA 174th Hospital, Xiamen, Fujian, ChinaThe prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans. The generalized linear model (GLM) was used to analyze the associations between seminal prosaposin concentrations and normal fertilization rates and good embryos proportion. The generalized estimating equation (GEE) was used to evaluate the association between embryo parameters and the prosaposin concentrations. Each model was adjusted for age of the couples, female basal FSH, AFC and BMI, starting dose and oocyte yield of IVF cycles and smoker. GLM models suggested that prosaposin was significantly associated with fertilization rate (P = 0.005) and good embryo proportion (P = 0.038) while none of the semen parameters (sperm concentration, motility, progressive motility, normal morphology rate, postwash sperm concentration and motility) was significantly associated with the parameters in the cohort. Using GEE, it was also shown that prosaposin was positively associated with the occurrence of early cleavage and negatively associated with uneven cleavage pattern on day 3. In both the overall population and the normozoospermia patients, the prosaposin was significantly associated with pregnancy with adjustment with covariates. In conclusion, our data suggested that seminal prosaposin concentration could provide more information regarding normal fertilization and embryo development in IVF than traditional semen parameters.https://peerj.com/articles/8177.pdfIVFSeminal plasmaFertilizationMale infertilityProsaposin |
| spellingShingle | Chun Xu Jiali Cai Lanlan Liu Jianzhi Ren Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles PeerJ IVF Seminal plasma Fertilization Male infertility Prosaposin |
| title | Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| title_full | Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| title_fullStr | Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| title_full_unstemmed | Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| title_short | Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| title_sort | prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles |
| topic | IVF Seminal plasma Fertilization Male infertility Prosaposin |
| url | https://peerj.com/articles/8177.pdf |
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