The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers
As the indications for the use of immunotherapy in genitourinary malignancies expand, its role in combination with standard or conventional therapies has become the subject of contemporary studies. Radiotherapy has multiple immunomodulating effects on anti-tumor immune response, which highlights pot...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/1/127 |
| _version_ | 1797626206433050624 |
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| author | Ava Saidian Isabella Dolendo Andrew Sharabi Tyler F. Stewart Brent Rose Rana R. McKay Aditya Bagrodia Amirali Salmasi |
| author_facet | Ava Saidian Isabella Dolendo Andrew Sharabi Tyler F. Stewart Brent Rose Rana R. McKay Aditya Bagrodia Amirali Salmasi |
| author_sort | Ava Saidian |
| collection | DOAJ |
| description | As the indications for the use of immunotherapy in genitourinary malignancies expand, its role in combination with standard or conventional therapies has become the subject of contemporary studies. Radiotherapy has multiple immunomodulating effects on anti-tumor immune response, which highlights potential synergistic role with immunotherapy agents. We sought to review the body of published data studying the combination of immunotherapy and radiotherapy as well as the rationale for combination therapy. Trial information and primary articles were obtained using the following terms “immunotherapy”, “radiotherapy”, “prostate cancer”, and “bladder cancer.” All articles and trials were screened to ensure they included combination radiotherapy and immunotherapy. The effects of radiation on the immune system, including both immunogenic and immunosuppressive effects, have been reported. There is a potential for combinatorial or synergistic effects between radiation therapy and immunotherapy in treating bladder and prostate cancers. However, results from ongoing and future clinical trials are needed to best integrate immunotherapy into current standard of care treatments for GU cancers. |
| first_indexed | 2024-03-11T10:07:10Z |
| format | Article |
| id | doaj.art-b9d5decb4b9c4e6dacfcffa8438662c8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:07:10Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b9d5decb4b9c4e6dacfcffa8438662c82023-11-16T15:01:59ZengMDPI AGCancers2072-66942022-12-0115112710.3390/cancers15010127The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary CancersAva Saidian0Isabella Dolendo1Andrew Sharabi2Tyler F. Stewart3Brent Rose4Rana R. McKay5Aditya Bagrodia6Amirali Salmasi7Department of Urology, University of California-San Diego, San Diego, CA 92121, USASchool of Medicine, University of California-San Diego, San Diego, CA 92093, USADepartment of Radiation Medicine and Applied Sciences, University of California-San Diego, San Diego, CA 92093, USADepartment of Medicine, University of California-San Diego, San Diego, CA 92161, USADepartment of Radiation Medicine and Applied Sciences, University of California-San Diego, San Diego, CA 92093, USADepartment of Medicine, University of California-San Diego, San Diego, CA 92161, USADepartment of Urology, University of California-San Diego, San Diego, CA 92121, USADepartment of Urology, University of California-San Diego, San Diego, CA 92121, USAAs the indications for the use of immunotherapy in genitourinary malignancies expand, its role in combination with standard or conventional therapies has become the subject of contemporary studies. Radiotherapy has multiple immunomodulating effects on anti-tumor immune response, which highlights potential synergistic role with immunotherapy agents. We sought to review the body of published data studying the combination of immunotherapy and radiotherapy as well as the rationale for combination therapy. Trial information and primary articles were obtained using the following terms “immunotherapy”, “radiotherapy”, “prostate cancer”, and “bladder cancer.” All articles and trials were screened to ensure they included combination radiotherapy and immunotherapy. The effects of radiation on the immune system, including both immunogenic and immunosuppressive effects, have been reported. There is a potential for combinatorial or synergistic effects between radiation therapy and immunotherapy in treating bladder and prostate cancers. However, results from ongoing and future clinical trials are needed to best integrate immunotherapy into current standard of care treatments for GU cancers.https://www.mdpi.com/2072-6694/15/1/127immunotherapyradiotherapyprostate cancerbladder cancergenitourinary malignancies |
| spellingShingle | Ava Saidian Isabella Dolendo Andrew Sharabi Tyler F. Stewart Brent Rose Rana R. McKay Aditya Bagrodia Amirali Salmasi The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers Cancers immunotherapy radiotherapy prostate cancer bladder cancer genitourinary malignancies |
| title | The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers |
| title_full | The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers |
| title_fullStr | The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers |
| title_full_unstemmed | The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers |
| title_short | The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers |
| title_sort | current and future promises of combination radiation and immunotherapy for genitourinary cancers |
| topic | immunotherapy radiotherapy prostate cancer bladder cancer genitourinary malignancies |
| url | https://www.mdpi.com/2072-6694/15/1/127 |
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