Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder
Xia Sun,1,* Xiandi Pan,2,* Kaiji Ni,1 Chenfeng Ji,1 Jiaxin Wu,3 Chao Yan,4 Yanli Luo1 1Department of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Pudong New Area Mental Health Center, Tongji Univers...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-01-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/aberrant-thalamic-centered-functional-connectivity-in-patients-with-pe-peer-reviewed-article-NDT |
| _version_ | 1818751152530915328 |
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| author | Sun X Pan X Ni K Ji C Wu J Yan C Luo Y |
| author_facet | Sun X Pan X Ni K Ji C Wu J Yan C Luo Y |
| author_sort | Sun X |
| collection | DOAJ |
| description | Xia Sun,1,* Xiandi Pan,2,* Kaiji Ni,1 Chenfeng Ji,1 Jiaxin Wu,3 Chao Yan,4 Yanli Luo1 1Department of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, People’s Republic of China; 4Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of China *These authors contributed equally to this workCorrespondence: Yanli LuoDepartment of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai 200127, People’s Republic of ChinaTel +86-21-68382998Email luoluoyanli@163.comChao YanKey Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, North Zhongshan Road 3663, Shanghai 200062, People’s Republic of ChinaTel +862162232963Email cyan@psy.ecnu.edu.cnPurpose: Recent task-based fMRI studies have shown that Persistent Somatoform Pain Disorder (PSPD) patients demonstrated aberrant activity in a wide range of brain regions associated with sensation, cognition and emotion. However, these specific task-based studies could not clearly uncover the alterations in the spontaneous brain networks that were associated with the general pain-related symptoms in PSPD.Patients and Methods: In the present study, 13 PSPD patients and 23 matched healthy controls (HCs) were enrolled. Resting state and 3D structural imaging data were collected during magnetic resonance imaging (MRI) scans. Ninety regions of interest (ROIs) were selected from the automated anatomical labeling (AAL) template. The functional connectivity toolbox “CONN” was used to calculate the functional connectivity (FC) coefficients.Results: Our results showed that PSPD patients exhibited increased FCs between the left thalamus and the right amygdala, the right hippocampus, and multiple sub-regions of the occipital lobe when compared to HCs. Correlation analysis revealed a negative correlation between the left thalamus-right amygdala FC and the level of anxiety in PSPD patients.Conclusion: These findings suggest that the altered FC between thalamus and amygdala may be the neural mechanisms underlying the pain-related anxiety in PSPD.Keywords: persistent somatoform pain disorder, functional magnetic resonance imaging, resting-state, functional connectivity
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| first_indexed | 2024-12-18T04:31:02Z |
| format | Article |
| id | doaj.art-b9d6163425c940a886fed330c1d60523 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-18T04:31:02Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-b9d6163425c940a886fed330c1d605232022-12-21T21:20:59ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212020-01-01Volume 1627328151349Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain DisorderSun XPan XNi KJi CWu JYan CLuo YXia Sun,1,* Xiandi Pan,2,* Kaiji Ni,1 Chenfeng Ji,1 Jiaxin Wu,3 Chao Yan,4 Yanli Luo1 1Department of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, People’s Republic of China; 4Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of China *These authors contributed equally to this workCorrespondence: Yanli LuoDepartment of Psychological Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pujian Road 160, Shanghai 200127, People’s Republic of ChinaTel +86-21-68382998Email luoluoyanli@163.comChao YanKey Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, North Zhongshan Road 3663, Shanghai 200062, People’s Republic of ChinaTel +862162232963Email cyan@psy.ecnu.edu.cnPurpose: Recent task-based fMRI studies have shown that Persistent Somatoform Pain Disorder (PSPD) patients demonstrated aberrant activity in a wide range of brain regions associated with sensation, cognition and emotion. However, these specific task-based studies could not clearly uncover the alterations in the spontaneous brain networks that were associated with the general pain-related symptoms in PSPD.Patients and Methods: In the present study, 13 PSPD patients and 23 matched healthy controls (HCs) were enrolled. Resting state and 3D structural imaging data were collected during magnetic resonance imaging (MRI) scans. Ninety regions of interest (ROIs) were selected from the automated anatomical labeling (AAL) template. The functional connectivity toolbox “CONN” was used to calculate the functional connectivity (FC) coefficients.Results: Our results showed that PSPD patients exhibited increased FCs between the left thalamus and the right amygdala, the right hippocampus, and multiple sub-regions of the occipital lobe when compared to HCs. Correlation analysis revealed a negative correlation between the left thalamus-right amygdala FC and the level of anxiety in PSPD patients.Conclusion: These findings suggest that the altered FC between thalamus and amygdala may be the neural mechanisms underlying the pain-related anxiety in PSPD.Keywords: persistent somatoform pain disorder, functional magnetic resonance imaging, resting-state, functional connectivity https://www.dovepress.com/aberrant-thalamic-centered-functional-connectivity-in-patients-with-pe-peer-reviewed-article-NDTpersistent somatoform pain disorderfunctional magnetic resonance imagingresting-statefunctional connectivity |
| spellingShingle | Sun X Pan X Ni K Ji C Wu J Yan C Luo Y Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder Neuropsychiatric Disease and Treatment persistent somatoform pain disorder functional magnetic resonance imaging resting-state functional connectivity |
| title | Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder |
| title_full | Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder |
| title_fullStr | Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder |
| title_full_unstemmed | Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder |
| title_short | Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder |
| title_sort | aberrant thalamic centered functional connectivity in patients with persistent somatoform pain disorder |
| topic | persistent somatoform pain disorder functional magnetic resonance imaging resting-state functional connectivity |
| url | https://www.dovepress.com/aberrant-thalamic-centered-functional-connectivity-in-patients-with-pe-peer-reviewed-article-NDT |
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