Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde
During 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not Afric...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2020-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/6/19-0928_article |
| _version_ | 1811214691141156864 |
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| author | Oumar Faye Maria de Lourdes Monteiro Bram Vrancken Matthieu Prot Sebastian Lequime Maryam Diarra Oumar Ndiaye Tomas Valdez Sandra Tavarez Jessica Ramos Silvânia da Veiga Leal Cecilio Pires Antonio Moreira Maria Filomena Tavares Linete Fernandes Jorge Noel Barreto Maria do Céu Teixeira Maria da Luz de Lima Mendonça Carolina Cardoso da Silva Leite Gomes Mariano Salazar Castellon Laurence Ma Frédéric Lemoine Fabiana Gámbaro-Roglia Déborah Delaune Gamou Fall Ibrahima Socé Fall Mamadou Diop Anavaj Sakuntabhai Cheikh Loucoubar Philippe Lemey Edward C. Holmes Ousmane Faye Amadou Alpha Sall Etienne Simon-Loriere |
| author_facet | Oumar Faye Maria de Lourdes Monteiro Bram Vrancken Matthieu Prot Sebastian Lequime Maryam Diarra Oumar Ndiaye Tomas Valdez Sandra Tavarez Jessica Ramos Silvânia da Veiga Leal Cecilio Pires Antonio Moreira Maria Filomena Tavares Linete Fernandes Jorge Noel Barreto Maria do Céu Teixeira Maria da Luz de Lima Mendonça Carolina Cardoso da Silva Leite Gomes Mariano Salazar Castellon Laurence Ma Frédéric Lemoine Fabiana Gámbaro-Roglia Déborah Delaune Gamou Fall Ibrahima Socé Fall Mamadou Diop Anavaj Sakuntabhai Cheikh Loucoubar Philippe Lemey Edward C. Holmes Ousmane Faye Amadou Alpha Sall Etienne Simon-Loriere |
| author_sort | Oumar Faye |
| collection | DOAJ |
| description | During 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1–2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations. |
| first_indexed | 2024-04-12T06:08:41Z |
| format | Article |
| id | doaj.art-b9d89aaff3e34b10ac9ebb7d77bbda96 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T06:08:41Z |
| publishDate | 2020-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-b9d89aaff3e34b10ac9ebb7d77bbda962022-12-22T03:44:46ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-06-012661084109010.3201/eid2606.190928Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape VerdeOumar FayeMaria de Lourdes MonteiroBram VranckenMatthieu ProtSebastian LequimeMaryam DiarraOumar NdiayeTomas ValdezSandra TavarezJessica RamosSilvânia da Veiga LealCecilio PiresAntonio MoreiraMaria Filomena TavaresLinete FernandesJorge Noel BarretoMaria do Céu TeixeiraMaria da Luz de Lima MendonçaCarolina Cardoso da Silva Leite GomesMariano Salazar CastellonLaurence MaFrédéric LemoineFabiana Gámbaro-RogliaDéborah DelauneGamou FallIbrahima Socé FallMamadou DiopAnavaj SakuntabhaiCheikh LoucoubarPhilippe LemeyEdward C. HolmesOusmane FayeAmadou Alpha SallEtienne Simon-LoriereDuring 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1–2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.https://wwwnc.cdc.gov/eid/article/26/6/19-0928_articleZika virusmicrocephalyCabo VerdeCape VerdeBrazilWestern Africa |
| spellingShingle | Oumar Faye Maria de Lourdes Monteiro Bram Vrancken Matthieu Prot Sebastian Lequime Maryam Diarra Oumar Ndiaye Tomas Valdez Sandra Tavarez Jessica Ramos Silvânia da Veiga Leal Cecilio Pires Antonio Moreira Maria Filomena Tavares Linete Fernandes Jorge Noel Barreto Maria do Céu Teixeira Maria da Luz de Lima Mendonça Carolina Cardoso da Silva Leite Gomes Mariano Salazar Castellon Laurence Ma Frédéric Lemoine Fabiana Gámbaro-Roglia Déborah Delaune Gamou Fall Ibrahima Socé Fall Mamadou Diop Anavaj Sakuntabhai Cheikh Loucoubar Philippe Lemey Edward C. Holmes Ousmane Faye Amadou Alpha Sall Etienne Simon-Loriere Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde Emerging Infectious Diseases Zika virus microcephaly Cabo Verde Cape Verde Brazil Western Africa |
| title | Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde |
| title_full | Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde |
| title_fullStr | Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde |
| title_full_unstemmed | Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde |
| title_short | Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde |
| title_sort | genomic epidemiology of 2015 2016 zika virus outbreak in cape verde |
| topic | Zika virus microcephaly Cabo Verde Cape Verde Brazil Western Africa |
| url | https://wwwnc.cdc.gov/eid/article/26/6/19-0928_article |
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