Pathological Consequences of Hepatic mTORC1 Dysregulation
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism that integrates environmental inputs, including nutrients, growth factors, and stress signals. mTORC1 activation upregulates anabolism of diverse macromolecules, such as proteins, lipids, and nucleic acids, whi...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/8/896 |
| _version_ | 1797560216691146752 |
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| author | Chun-Seok Cho Allison Ho Kowalsky Jun Hee Lee |
| author_facet | Chun-Seok Cho Allison Ho Kowalsky Jun Hee Lee |
| author_sort | Chun-Seok Cho |
| collection | DOAJ |
| description | The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism that integrates environmental inputs, including nutrients, growth factors, and stress signals. mTORC1 activation upregulates anabolism of diverse macromolecules, such as proteins, lipids, and nucleic acids, while downregulating autolysosomal catabolism. mTORC1 dysregulation is often found in various diseases, including cancer, cardiovascular and neurodegenerative diseases, as well as metabolic syndromes involving obesity and type II diabetes. As an essential metabolic organ, the liver requires proper regulation of mTORC1 for maintaining homeostasis and preventing pathologies. For instance, aberrant hyper- or hypoactivation of mTORC1 disrupts hepatocellular homeostasis and damages the structural and functional integrity of the tissue, leading to prominent liver injury and the development of hepatocellular carcinogenesis. Proper regulation of mTORC1 during liver diseases may be beneficial for restoring liver function and ameliorating the detrimental consequences of liver failure. |
| first_indexed | 2024-03-10T17:57:18Z |
| format | Article |
| id | doaj.art-b9d8e521e9314d55a93239550729f0ec |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T17:57:18Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b9d8e521e9314d55a93239550729f0ec2023-11-20T09:10:36ZengMDPI AGGenes2073-44252020-08-0111889610.3390/genes11080896Pathological Consequences of Hepatic mTORC1 DysregulationChun-Seok Cho0Allison Ho Kowalsky1Jun Hee Lee2Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USADepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USADepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USAThe mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism that integrates environmental inputs, including nutrients, growth factors, and stress signals. mTORC1 activation upregulates anabolism of diverse macromolecules, such as proteins, lipids, and nucleic acids, while downregulating autolysosomal catabolism. mTORC1 dysregulation is often found in various diseases, including cancer, cardiovascular and neurodegenerative diseases, as well as metabolic syndromes involving obesity and type II diabetes. As an essential metabolic organ, the liver requires proper regulation of mTORC1 for maintaining homeostasis and preventing pathologies. For instance, aberrant hyper- or hypoactivation of mTORC1 disrupts hepatocellular homeostasis and damages the structural and functional integrity of the tissue, leading to prominent liver injury and the development of hepatocellular carcinogenesis. Proper regulation of mTORC1 during liver diseases may be beneficial for restoring liver function and ameliorating the detrimental consequences of liver failure.https://www.mdpi.com/2073-4425/11/8/896mTORC1livermetabolism |
| spellingShingle | Chun-Seok Cho Allison Ho Kowalsky Jun Hee Lee Pathological Consequences of Hepatic mTORC1 Dysregulation Genes mTORC1 liver metabolism |
| title | Pathological Consequences of Hepatic mTORC1 Dysregulation |
| title_full | Pathological Consequences of Hepatic mTORC1 Dysregulation |
| title_fullStr | Pathological Consequences of Hepatic mTORC1 Dysregulation |
| title_full_unstemmed | Pathological Consequences of Hepatic mTORC1 Dysregulation |
| title_short | Pathological Consequences of Hepatic mTORC1 Dysregulation |
| title_sort | pathological consequences of hepatic mtorc1 dysregulation |
| topic | mTORC1 liver metabolism |
| url | https://www.mdpi.com/2073-4425/11/8/896 |
| work_keys_str_mv | AT chunseokcho pathologicalconsequencesofhepaticmtorc1dysregulation AT allisonhokowalsky pathologicalconsequencesofhepaticmtorc1dysregulation AT junheelee pathologicalconsequencesofhepaticmtorc1dysregulation |