Development of a G2/M arrest high-throughput screening method identifies potent radiosensitizers

Development of a G2/M arrest high-throughput screening method identifies potent radiosensitizers

Radiation is a powerful tool used to control tumor growth and induce an immune response; however, it is limited by damage to surrounding tissue and adverse effects such skin irritation. Breast cancer patients in particular may endure radiation dermatitis, and potentially lymphedema, after a course o...

Full description

Bibliographic Details
Main Authors:	Madeleine Landry, Dylan Nelson, Eunseo Choi, Allison DuRoss, Conroy Sun
Format:	Article
Language:	English
Published:	Elsevier 2022-02-01
Series:	Translational Oncology
Subjects:	High-content imaging Proflavine hemisulfate Cell cycle analysis X-ray Radiation therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523321003272

Similar Items

Efficient Plant Regeneration via Indirect Organogenesis in Carnation (Dianthus caryophyllus semperflorens flore pleno) Cultivars
by: Sabaghi Hamid Reza, et al.
Published: (2021-12-01)

The role of S-methylisothiourea hemisulfate as inducible nitric oxide synthase inhibitor against kidney iron deposition in iron overload rats
by: Maryam Maleki, et al.
Published: (2016-01-01)

Comparative Study Regarding the Properties of Methylene Blue and Proflavine and Their Optimal Concentrations for In Vitro and In Vivo Applications
by: Maria-Eliza Nedu, et al.
Published: (2020-04-01)

Synthesis of Novel Biologically Active Proflavine Ureas Designed on the Basis of Predicted Entropy Changes
by: Ladislav Janovec, et al.
Published: (2021-08-01)

Photo-activated proflavine degrades protein and impairs enzyme activity: Involvement of hydroxyl radicals
by: Mansour K. Gatasheh, et al.
Published: (2022-01-01)

Methylene Blue and Proflavine as Intraarterial Marker for Functional Perforazome—Comparative Study
by: Maria-Eliza Nedu, et al.
Published: (2021-02-01)

Generation of Oxygen Free Radicals by Proflavine: Implication in Protein Degradation
by: Mansour K.M. Gatasheh, et al.
Published: (2018-03-01)

Generation of Oxygen Free Radicals by Proflavine: Implication in Protein Degradation
by: Mansour K.M. Gatasheh, et al.
Published: (2017-07-01)

Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex
by: Jie Zhou, et al.
Published: (2022-11-01)

Electrochemical DNA Sensor Based on the Copolymer of Proflavine and Azure B for Doxorubicin Determination
by: Anna Porfireva, et al.
Published: (2020-05-01)

Mitochondrial Metabolism in X-Irradiated Cells Undergoing Irreversible Cell-Cycle Arrest
by: Eri Hirose, et al.
Published: (2023-01-01)

Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells
by: Eva Brack, et al.
Published: (2021-06-01)

A siRNA screen to identify molecular determinants of tumour radiosensitivity
by: Higgins, G, et al.
Published: (2010)

Formulation of Folate-Modified Raltitrexed-Loaded Nanoparticles for Colorectal Cancer Theranostics
by: Justin G. Rosch, et al.
Published: (2020-02-01)

Development of a Pemetrexed/Folic Acid Nanoformulation: Synthesis, Characterization, and Efficacy in a Murine Colorectal Cancer Model
by: Justin G. Rosch, et al.
Published: (2020-06-01)

Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening
by: Rosette N. Tamaddondoust, et al.
Published: (2022-08-01)

Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles
by: Shi M, et al.
Published: (2016-10-01)

ZNF582 promoter methylation predicts cervical cancer radiosensitivity and ZNF582 protein overexpression reduces radiosensitivity by cell cycle arrest in S phase
by: Nayiyuan Wu, et al.
Published: (2022-12-01)

Ligand-induced DNA conformational changes in proflavine minor groove-bound complexes studied by molecular dynamics simulation
by: K. V. Miroshnychenko, et al.
Published: (2019-04-01)

Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity
by: Juan C. Alamilla-Presuel
Published: (2023-09-01)

Estimation of absorbed dose of radiosensitive organs and effective sose in patients underwent abdominopelvic spiral CT scan using impact CT patient dosimetry
by: Ayoub Amirnia, et al.
Published: (2017-05-01)

Proflavine (PFH+): as a photosensitizer (PS) biocatalyst for the visible-light-induced synthesis of pyrano [2,3-d] pyrimidine scaffolds
by: Farzaneh Mohamadpour, et al.
Published: (2024-03-01)

Radiosensitizers, radioprotectors, and radiation mitigators
by: Jayam Raviraj, et al.
Published: (2014-01-01)

Radiosensitization Effect of Gold Nanoparticles on Plasmid DNA Damage Induced by Therapeutic MV X-rays
by: Katsunori Yogo, et al.
Published: (2022-02-01)

Selenium speciation-dependent cancer radiosensitization by induction of G2/M cell cycle arrest and apoptosis
by: Shiqing Nie, et al.
Published: (2023-03-01)

Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma
by: Anne‐Laure Bulin, et al.
Published: (2020-10-01)

Prosedur kecemasan /
by: 564772 Ahmad Termizi Ramli, et al.

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells
by: Roberto Gomez-Casal, et al.
Published: (2015-05-01)

Estimation of Cosmic-Ray-Induced Atmospheric Ionization and Radiation at Commercial Aviation Flight Altitudes
by: Panagiota Makrantoni, et al.
Published: (2022-05-01)

Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux
by: Surendra Kumar Prajapat, et al.
Published: (2022-12-01)

Genomic identification of sarcoma radiosensitivity and the clinical implications for radiation dose personalization
by: George Yang, et al.
Published: (2021-10-01)

Human Radiosensitivity and Radiosusceptibility: What Are the Differences?
by: Laura El-Nachef, et al.
Published: (2021-07-01)

Translational Implications for Radiosensitizing Strategies in Rhabdomyosarcoma
by: Silvia Pomella, et al.
Published: (2022-10-01)

Predicting Factors of Radiosensitivity in Individual Radiotherapy
by: Sh ghasemi, et al.
Published: (2015-10-01)

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
by: Vasiliki Zoi, et al.
Published: (2022-01-01)

The role of nitric oxide as a hypoxic cell radiosensitizer
by: Folkes, L
Published: (2013)

Harnessing Lactate Metabolism for Radiosensitization
by: Kevin X. Liu, et al.
Published: (2021-07-01)

Advanced materials and techniques for radiation dosimetry /
by: Arshak, Khalil, et al.
Published: (2006)

Radiation contrast improvement by suitable choice of x-ray radiation spectrum
by: Mazin F. Mahrok
Published: (2011-01-01)

Hypoxia Modulates Radiosensitivity and Response to Different Radiation Qualities in A549 Non-Small Cell Lung Cancer (NSCLC) Cells
by: Hasan Nisar, et al.
Published: (2024-01-01)