Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin
In recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2023-12-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.008 |
| _version_ | 1797249378577022976 |
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| author | Xinling CHEN Yu SUN Yuhan JIANG Yue ZHENG |
| author_facet | Xinling CHEN Yu SUN Yuhan JIANG Yue ZHENG |
| author_sort | Xinling CHEN |
| collection | DOAJ |
| description | In recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic and functional changes in the skin microenvironment, and directly and indirectly alter the skin immune microenvironment. UVR induces immunosuppression, including activation of regulatory T cells and alterations in the number and function of antigen-presenting cells. The interactions among B cells, T cells, Langerhans cells and mast cells play an important role in UVR-induced immunosuppression. In addition, the effects of UVR on T cell co-inhibitory and co-stimulatory signals have been increasingly appreciated. In this paper, we review the recent progress in the imbalance of the immune microenvironment in the chronically photodamaged skin. |
| first_indexed | 2024-04-24T20:29:32Z |
| format | Article |
| id | doaj.art-b9da44c857a943f19cedb99837c194b9 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-04-24T20:29:32Z |
| publishDate | 2023-12-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-b9da44c857a943f19cedb99837c194b92024-03-22T02:46:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-12-0130652953310.3969/j.issn.1674-8468.2023.06.008Advances in the imbalance of the immune microenvironment in the chronically photodamaged skinXinling CHEN0Yu SUN1Yuhan JIANG2Yue ZHENG3Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaThird Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaIn recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic and functional changes in the skin microenvironment, and directly and indirectly alter the skin immune microenvironment. UVR induces immunosuppression, including activation of regulatory T cells and alterations in the number and function of antigen-presenting cells. The interactions among B cells, T cells, Langerhans cells and mast cells play an important role in UVR-induced immunosuppression. In addition, the effects of UVR on T cell co-inhibitory and co-stimulatory signals have been increasingly appreciated. In this paper, we review the recent progress in the imbalance of the immune microenvironment in the chronically photodamaged skin.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.008solar ultraviolet lightimmune microenvironmentskin immunitytumor immunityphotoaging |
| spellingShingle | Xinling CHEN Yu SUN Yuhan JIANG Yue ZHENG Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin Pifu-xingbing zhenliaoxue zazhi solar ultraviolet light immune microenvironment skin immunity tumor immunity photoaging |
| title | Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| title_full | Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| title_fullStr | Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| title_full_unstemmed | Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| title_short | Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| title_sort | advances in the imbalance of the immune microenvironment in the chronically photodamaged skin |
| topic | solar ultraviolet light immune microenvironment skin immunity tumor immunity photoaging |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.008 |
| work_keys_str_mv | AT xinlingchen advancesintheimbalanceoftheimmunemicroenvironmentinthechronicallyphotodamagedskin AT yusun advancesintheimbalanceoftheimmunemicroenvironmentinthechronicallyphotodamagedskin AT yuhanjiang advancesintheimbalanceoftheimmunemicroenvironmentinthechronicallyphotodamagedskin AT yuezheng advancesintheimbalanceoftheimmunemicroenvironmentinthechronicallyphotodamagedskin |