Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer
Abstract Background and Aim New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell‐derived protein complexes containing RNA that can be used as indicators of cancer development. The aim of this review is to evaluate the current litera...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12848 |
| _version_ | 1828064280473239552 |
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| author | Menazir Sha Basir Kunduzi Saied Froghi Alberto Quaglia Brian Davidson Giuseppe K Fusai |
| author_facet | Menazir Sha Basir Kunduzi Saied Froghi Alberto Quaglia Brian Davidson Giuseppe K Fusai |
| author_sort | Menazir Sha |
| collection | DOAJ |
| description | Abstract Background and Aim New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell‐derived protein complexes containing RNA that can be used as indicators of cancer development. The aim of this review is to evaluate the current literature involving PC patient groups for highly accurate exosomal biomarkers. Methods The literature search followed Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Eight‐hundred and seventy‐five studies were identified across various databases (Ovid MEDLINE, Embase, and Cochrane) published between 2009 and 2020. Nine studies fulfilled the inclusion criteria: human PC patients, diagnosis as outcome of interest, serum biomarker of exosomal content, reporting of diagnostic values, and disease progress. Area under the curve (AUC) of the exosomal biomarker was compared against that of CA19‐9. Results Nine papers were reviewed for relevant outcomes based on the inclusion criteria. These studies involved 565 participants (331 PC, 234 controls; male/female ratio 1.21; mean age 64.1). Tumor staging was reported in all studies, with 45.6% of PC patients diagnosed with early‐stage PC (T1–2). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1) and GPC 1 reported the highest performing sensitivity and specificity at 100% each. The microRNA panel (miR‐10b, miR‐21, miR‐30c, miR‐181a, and miR‐let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. Five studies compared the AUC of the exosomal biomarker against CA19‐9, each being superior to that of CA19‐9. Conclusion The potential of exosomal biomarkers remains promising in PC diagnosis. Standardization of future studies will allow for larger comparative analyses and overcoming contrasting findings. |
| first_indexed | 2024-04-10T22:56:08Z |
| format | Article |
| id | doaj.art-b9dc31d8f7c141ffb5349ace1bdc01de |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-04-10T22:56:08Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-b9dc31d8f7c141ffb5349ace1bdc01de2023-01-14T11:33:20ZengWileyJGH Open2397-90702023-01-0171303910.1002/jgh3.12848Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancerMenazir Sha0Basir Kunduzi1Saied Froghi2Alberto Quaglia3Brian Davidson4Giuseppe K Fusai5University College London, Medical School London UKRenal Transplant Unit Guy's Hospital London UKDivision of Surgery and Interventional Sciences/UCL Royal Free Hospital London UKDepartment of Cellular Pathology Royal Free Hospital London UKDivision of Surgery and Interventional Sciences/UCL Royal Free Hospital London UKDivision of Surgery and Interventional Sciences/UCL Royal Free Hospital London UKAbstract Background and Aim New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell‐derived protein complexes containing RNA that can be used as indicators of cancer development. The aim of this review is to evaluate the current literature involving PC patient groups for highly accurate exosomal biomarkers. Methods The literature search followed Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Eight‐hundred and seventy‐five studies were identified across various databases (Ovid MEDLINE, Embase, and Cochrane) published between 2009 and 2020. Nine studies fulfilled the inclusion criteria: human PC patients, diagnosis as outcome of interest, serum biomarker of exosomal content, reporting of diagnostic values, and disease progress. Area under the curve (AUC) of the exosomal biomarker was compared against that of CA19‐9. Results Nine papers were reviewed for relevant outcomes based on the inclusion criteria. These studies involved 565 participants (331 PC, 234 controls; male/female ratio 1.21; mean age 64.1). Tumor staging was reported in all studies, with 45.6% of PC patients diagnosed with early‐stage PC (T1–2). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1) and GPC 1 reported the highest performing sensitivity and specificity at 100% each. The microRNA panel (miR‐10b, miR‐21, miR‐30c, miR‐181a, and miR‐let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. Five studies compared the AUC of the exosomal biomarker against CA19‐9, each being superior to that of CA19‐9. Conclusion The potential of exosomal biomarkers remains promising in PC diagnosis. Standardization of future studies will allow for larger comparative analyses and overcoming contrasting findings.https://doi.org/10.1002/jgh3.12848cancer biomarkerexosomal biomarkerpancreatic cancer |
| spellingShingle | Menazir Sha Basir Kunduzi Saied Froghi Alberto Quaglia Brian Davidson Giuseppe K Fusai Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer JGH Open cancer biomarker exosomal biomarker pancreatic cancer |
| title | Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| title_full | Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| title_fullStr | Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| title_full_unstemmed | Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| title_short | Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| title_sort | role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer |
| topic | cancer biomarker exosomal biomarker pancreatic cancer |
| url | https://doi.org/10.1002/jgh3.12848 |
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