The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients
Xiaoye Yuan, Caixia Lv, Sisi Wu, Huiying Wang, Xiaoyu Liu Department of Geriatric Cardiovascular, Hebei General Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Xiaoye Yuan, Department of Geriatric Cardiovascular, Hebei General Hospital, No. 348, Heping West Road, Shijiazhua...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-03-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-predictive-value-of-hemoglobin-to-red-cell-blood-distribution-widt-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797269826081652736 |
|---|---|
| author | Yuan X Lv C Wu S Wang H Liu X |
| author_facet | Yuan X Lv C Wu S Wang H Liu X |
| author_sort | Yuan X |
| collection | DOAJ |
| description | Xiaoye Yuan, Caixia Lv, Sisi Wu, Huiying Wang, Xiaoyu Liu Department of Geriatric Cardiovascular, Hebei General Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Xiaoye Yuan, Department of Geriatric Cardiovascular, Hebei General Hospital, No. 348, Heping West Road, Shijiazhuang, 050000, People’s Republic of China, Tel +86-15511308370, Email yxymoon2000@163.comPurpose: To investigate the predictive value of hemoglobin (Hb) to red blood cell distribution width (RDW) (Hb/RDW) ratio in combination with serum sodium for major adverse cardiovascular events (MACE) in elderly acute heart failure patients with preserved ejection fraction at 30 days after discharge.Methods: 130 elderly acute heart failure patients with preserved ejection fraction were enrolled and followed up at 30 days after discharge. They were classified into the MACE group (n=11) and none-MACE group (n=119). On the day of admission, clinical baseline characteristics were measured and results from laboratory tests were gathered. The correlation and predictive value of Hb/RDW and serum sodium with the occurrence of MACE at 30 days after discharge in acute heart failure patients with preserved ejection fraction in the elderly were analyzed.Results: Spearman correlation analysis showed that the occurrence of MACE was negatively correlated with Hb/RDW, serum sodium (r=− 0.209, r=0.291, p< 0.05) and Hb/RDW (OR=0.484, 95% CI:0.254, 0.922), serum sodium (OR=0.779, 95% CI:0.646,0.939) were independent risk factors (p< 0.05) analyzed by multifactorial logistic. Receiver operating characteristic curves (ROC) analysis showed that the area under the curve (AUC) for the prediction of MACE by Hb/RDW was 0.73, with an optimal threshold of 9.28, sensitivity 81.80%, specificity 70.60%, positive predictive value (PPV) 20.50%, negative predictive value (NPV) 97.70%; the AUC of serum sodium for predicting the occurrence of MACE was 0.76, with an optimal threshold of 140.35 mmol/L, sensitivity 90.90%, specificity 57.10%, PPV 16.40%, NPV 98.60%; and the AUC of Hb/RDW combined serum sodium to predict the occurrence of MACE was 0.83, with sensitivity 90.90%, specificity 78.20%, PPV 27.80% and NPV 98.90%.Conclusion: Hb/RDW and serum sodium had negative correlation with MACE and were independent risk factors of 30-day MACE; Hb/RDW combined with serum sodium can predict 30-day MACE occurrence in elderly acute heart failure patients with preserved ejection fraction.Keywords: hemoglobin to red cell blood distribution width ratio, serum sodium, acute heart failure, MACE, predictive value, elderly |
| first_indexed | 2024-04-25T01:54:32Z |
| format | Article |
| id | doaj.art-b9dc7bf92c6342aabf6326dcc17bb41d |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-25T01:54:32Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-b9dc7bf92c6342aabf6326dcc17bb41d2024-03-07T17:38:47ZengDove Medical PressInternational Journal of General Medicine1178-70742024-03-01Volume 1786387090979The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly PatientsYuan XLv CWu SWang HLiu XXiaoye Yuan, Caixia Lv, Sisi Wu, Huiying Wang, Xiaoyu Liu Department of Geriatric Cardiovascular, Hebei General Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Xiaoye Yuan, Department of Geriatric Cardiovascular, Hebei General Hospital, No. 348, Heping West Road, Shijiazhuang, 050000, People’s Republic of China, Tel +86-15511308370, Email yxymoon2000@163.comPurpose: To investigate the predictive value of hemoglobin (Hb) to red blood cell distribution width (RDW) (Hb/RDW) ratio in combination with serum sodium for major adverse cardiovascular events (MACE) in elderly acute heart failure patients with preserved ejection fraction at 30 days after discharge.Methods: 130 elderly acute heart failure patients with preserved ejection fraction were enrolled and followed up at 30 days after discharge. They were classified into the MACE group (n=11) and none-MACE group (n=119). On the day of admission, clinical baseline characteristics were measured and results from laboratory tests were gathered. The correlation and predictive value of Hb/RDW and serum sodium with the occurrence of MACE at 30 days after discharge in acute heart failure patients with preserved ejection fraction in the elderly were analyzed.Results: Spearman correlation analysis showed that the occurrence of MACE was negatively correlated with Hb/RDW, serum sodium (r=− 0.209, r=0.291, p< 0.05) and Hb/RDW (OR=0.484, 95% CI:0.254, 0.922), serum sodium (OR=0.779, 95% CI:0.646,0.939) were independent risk factors (p< 0.05) analyzed by multifactorial logistic. Receiver operating characteristic curves (ROC) analysis showed that the area under the curve (AUC) for the prediction of MACE by Hb/RDW was 0.73, with an optimal threshold of 9.28, sensitivity 81.80%, specificity 70.60%, positive predictive value (PPV) 20.50%, negative predictive value (NPV) 97.70%; the AUC of serum sodium for predicting the occurrence of MACE was 0.76, with an optimal threshold of 140.35 mmol/L, sensitivity 90.90%, specificity 57.10%, PPV 16.40%, NPV 98.60%; and the AUC of Hb/RDW combined serum sodium to predict the occurrence of MACE was 0.83, with sensitivity 90.90%, specificity 78.20%, PPV 27.80% and NPV 98.90%.Conclusion: Hb/RDW and serum sodium had negative correlation with MACE and were independent risk factors of 30-day MACE; Hb/RDW combined with serum sodium can predict 30-day MACE occurrence in elderly acute heart failure patients with preserved ejection fraction.Keywords: hemoglobin to red cell blood distribution width ratio, serum sodium, acute heart failure, MACE, predictive value, elderlyhttps://www.dovepress.com/the-predictive-value-of-hemoglobin-to-red-cell-blood-distribution-widt-peer-reviewed-fulltext-article-IJGM: hemoglobin to red cell blood distribution width ratioserum sodiumacute heart failuremacepredictive valueelderly. |
| spellingShingle | Yuan X Lv C Wu S Wang H Liu X The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients International Journal of General Medicine : hemoglobin to red cell blood distribution width ratio serum sodium acute heart failure mace predictive value elderly. |
| title | The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients |
| title_full | The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients |
| title_fullStr | The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients |
| title_full_unstemmed | The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients |
| title_short | The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients |
| title_sort | predictive value of hemoglobin to red cell blood distribution width ratio combined with serum sodium for mace of acute heart failure with preserved ejection fraction in elderly patients |
| topic | : hemoglobin to red cell blood distribution width ratio serum sodium acute heart failure mace predictive value elderly. |
| url | https://www.dovepress.com/the-predictive-value-of-hemoglobin-to-red-cell-blood-distribution-widt-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT yuanx thepredictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT lvc thepredictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT wus thepredictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT wangh thepredictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT liux thepredictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT yuanx predictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT lvc predictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT wus predictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT wangh predictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients AT liux predictivevalueofhemoglobintoredcellblooddistributionwidthratiocombinedwithserumsodiumformaceofacuteheartfailurewithpreservedejectionfractioninelderlypatients |