Endogenous excess cortisol production and diabetes mellitus as predisposing factors for pulmonary cryptococcosis: A case report and literature review
Pulmonary cryptococcosis usually occurs as an opportunistic infection in immuno-compromised patients. Endogenous <i>Cushing′s </i>syndrome is associated with cortisol excess and can predispose to development of cryptococcal infections. We report a case of diabetic patient with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2008-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2008;volume=25;issue=4;spage=155;epage=157;aulast=Thangakunam |
| Summary: | Pulmonary cryptococcosis usually occurs as an opportunistic infection in immuno-compromised patients. Endogenous <i>Cushing′s </i>syndrome is associated with cortisol excess and can predispose to development of cryptococcal infections. We report a case of diabetic patient with ACTH secreting pituitary tumour who developed a cavitating lung mass. Computed tomography-guided biopsy of the lesion revealed mucicarminophilic budding forms of cryptococcus. Broncheoalveolar lavage culture grew Cryptococcus neoformans. There was radiological response to treatment with liposomal Amphotericin, but patient ultimately succumbed to septicemia and multiorgan failure. Opportunistic infections with organisms like Cryptococcus neoformans, should be considered in patients with en-dogenous <i>Cushing′s </i>syndrome and a pulmonary infiltrate. |
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| ISSN: | 0970-2113 0974-598X |