Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia
Altered neurodevelopment and plasticity are implicated in schizophrenia pathology. Based on the important role of neurotrophic factors in brain development and plasticity as well as their extensive expression in hippocampal areas, we hypothesized that a variation in the neurotrophin receptor 3 gene...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109000631 |
| _version_ | 1819119952382132224 |
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| author | Mona K. Otnæss Srdjan Djurovic Lars M. Rimol Bettina Kulle Anna K. Kähler Erik G. Jönsson Ingrid Agartz Kjetil Sundet Håkan Hall Sally Timm Thomas Hansen Joseph H. Callicott Ingrid Melle Thomas Werge Ole A. Andreassen |
| author_facet | Mona K. Otnæss Srdjan Djurovic Lars M. Rimol Bettina Kulle Anna K. Kähler Erik G. Jönsson Ingrid Agartz Kjetil Sundet Håkan Hall Sally Timm Thomas Hansen Joseph H. Callicott Ingrid Melle Thomas Werge Ole A. Andreassen |
| author_sort | Mona K. Otnæss |
| collection | DOAJ |
| description | Altered neurodevelopment and plasticity are implicated in schizophrenia pathology. Based on the important role of neurotrophic factors in brain development and plasticity as well as their extensive expression in hippocampal areas, we hypothesized that a variation in the neurotrophin receptor 3 gene (NTRK-3) is associated to hippocampal function and schizophrenia. Thirty-three tagging NTRK-3 single nucleotide polymorphisms (SNPs) were genotyped in 839 schizophrenia patients and 1473 healthy controls. SNPs that were significantly associated with schizophrenia were evaluated in subgroups of the sample with neuropsychological test battery (n=104 patients and 175 controls) and functional magnetic resonance imaging tests of hippocampal function (n=36 controls). rs999905 was nominally significantly associated with schizophrenia and the haplotype block that included markers rs999905 and rs4887348 remained significant after permutation tests. These gene variants are also related to in vivo brain function in healthy control subjects, shown by a significant association with hippocampal activation during an encoding task. The present results, although not robust, suggest that the NTRK-3 gene influences hippocampal function and may modify the risk for schizophrenia. |
| first_indexed | 2024-12-22T06:12:57Z |
| format | Article |
| id | doaj.art-b9ddaebcaeee48cba5a430ae44a4fa9c |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T06:12:57Z |
| publishDate | 2009-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-b9ddaebcaeee48cba5a430ae44a4fa9c2022-12-21T18:36:11ZengElsevierNeurobiology of Disease1095-953X2009-06-01343518524Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophreniaMona K. Otnæss0Srdjan Djurovic1Lars M. Rimol2Bettina Kulle3Anna K. Kähler4Erik G. Jönsson5Ingrid Agartz6Kjetil Sundet7Håkan Hall8Sally Timm9Thomas Hansen10Joseph H. Callicott11Ingrid Melle12Thomas Werge13Ole A. Andreassen14Institute of Psychiatry, University of Oslo, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, NorwayInstitute of Psychiatry, University of Oslo, Oslo, Norway; Department of Medical Genetics, Ulleval University Hospital, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, Norway; Corresponding author. Department of Medical Genetics, Ullevål University Hospital, Kirkeveien 166, 0407 Oslo, Norway. Fax: +47 22 11 98 99.Institute of Psychiatry, University of Oslo, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, NorwayEpi-Gen, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway; Department of Biostatistics, University of Oslo, Oslo, NorwayInstitute of Psychiatry, University of Oslo, Oslo, Norway; Department of Medical Genetics, Ulleval University Hospital, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, NorwayDepartment of Clinical Neuroscience, HUBIN Project, Karolinska Institutet and Hospital, Stockholm, SwedenInstitute of Psychiatry, University of Oslo, Oslo, Norway; Department of Clinical Neuroscience, HUBIN Project, Karolinska Institutet and Hospital, Stockholm, Sweden; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NorwayInstitute of Psychology, University of Oslo, Oslo, NorwayDepartment of Clinical Neuroscience, HUBIN Project, Karolinska Institutet and Hospital, Stockholm, SwedenMental Health Centre Frederiksberg, Copenhagen University Hospital, Frederiksberg, DenmarkResearch Institute of Biological Psychiatry, Mental Health Center Sct. Hans Copenhagen University Hospital, Roskilde, DenmarkNational Institute of Mental Health, Bethesda, Maryland, USAInstitute of Psychiatry, University of Oslo, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, NorwayResearch Institute of Biological Psychiatry, Mental Health Center Sct. Hans Copenhagen University Hospital, Roskilde, DenmarkInstitute of Psychiatry, University of Oslo, Oslo, Norway; Department for Research and Development, Division of Psychiatry, Ulleval University Hospital Oslo, NorwayAltered neurodevelopment and plasticity are implicated in schizophrenia pathology. Based on the important role of neurotrophic factors in brain development and plasticity as well as their extensive expression in hippocampal areas, we hypothesized that a variation in the neurotrophin receptor 3 gene (NTRK-3) is associated to hippocampal function and schizophrenia. Thirty-three tagging NTRK-3 single nucleotide polymorphisms (SNPs) were genotyped in 839 schizophrenia patients and 1473 healthy controls. SNPs that were significantly associated with schizophrenia were evaluated in subgroups of the sample with neuropsychological test battery (n=104 patients and 175 controls) and functional magnetic resonance imaging tests of hippocampal function (n=36 controls). rs999905 was nominally significantly associated with schizophrenia and the haplotype block that included markers rs999905 and rs4887348 remained significant after permutation tests. These gene variants are also related to in vivo brain function in healthy control subjects, shown by a significant association with hippocampal activation during an encoding task. The present results, although not robust, suggest that the NTRK-3 gene influences hippocampal function and may modify the risk for schizophrenia.http://www.sciencedirect.com/science/article/pii/S0969996109000631NTRK3NT-3SNPSchizophreniaMemoryHippocampus |
| spellingShingle | Mona K. Otnæss Srdjan Djurovic Lars M. Rimol Bettina Kulle Anna K. Kähler Erik G. Jönsson Ingrid Agartz Kjetil Sundet Håkan Hall Sally Timm Thomas Hansen Joseph H. Callicott Ingrid Melle Thomas Werge Ole A. Andreassen Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia Neurobiology of Disease NTRK3 NT-3 SNP Schizophrenia Memory Hippocampus |
| title | Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia |
| title_full | Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia |
| title_fullStr | Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia |
| title_full_unstemmed | Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia |
| title_short | Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia |
| title_sort | evidence for a possible association of neurotrophin receptor ntrk 3 gene polymorphisms with hippocampal function and schizophrenia |
| topic | NTRK3 NT-3 SNP Schizophrenia Memory Hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S0969996109000631 |
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