Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers
The management of plaque psoriasis that affects difficult-to-treat areas can be challenging. Biologics have become the treatment of choice for moderate-to-severe plaque psoriasis. However, there are limited data on their efficacy in difficult-to-treat sites (including scalp, palms/soles, nails and g...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2023.2220849 |
| _version_ | 1827816502952198144 |
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| author | Diego Orsini Luigi Gargiulo Luciano Ibba Ruggero Cascio Ingurgio Mario Valenti Chiara Perugini Alessia Pacifico Fabio S. Maramao Pasquale Frascione Antonio Costanzo Alessandra Narcisi |
| author_facet | Diego Orsini Luigi Gargiulo Luciano Ibba Ruggero Cascio Ingurgio Mario Valenti Chiara Perugini Alessia Pacifico Fabio S. Maramao Pasquale Frascione Antonio Costanzo Alessandra Narcisi |
| author_sort | Diego Orsini |
| collection | DOAJ |
| description | The management of plaque psoriasis that affects difficult-to-treat areas can be challenging. Biologics have become the treatment of choice for moderate-to-severe plaque psoriasis. However, there are limited data on their efficacy in difficult-to-treat sites (including scalp, palms/soles, nails and genitalia). We conducted a 52-week retrospective study to evaluate the effectiveness of risankizumab in 202 patients with moderate-to-severe involvement of at least one difficult-to-treat area. One hundred and sixty-five patients had scalp psoriasis, 21 had involvement of palms or soles, 72 were affected by genital psoriasis, and 50 patients reported the involvement of the fingernails. After one year of treatment, 97.58% of patients with scalp involvement, 95.28% of patients with palmoplantar psoriasis, 100% of patients with genital psoriasis and 82% of patients with nail involvement achieved a site-specific Physician’s Global Assessment of 0 or 1 (clear or almost clear). No serious adverse events were observed during the study. Our study supports the effectiveness of risankizumab in plaque psoriasis involving difficult-to-treat sites. |
| first_indexed | 2024-03-12T00:15:15Z |
| format | Article |
| id | doaj.art-b9ddbcf12494443c97024bc2238bfb72 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:15Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-b9ddbcf12494443c97024bc2238bfb722023-09-15T14:28:53ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532023-12-0134110.1080/09546634.2023.22208492220849Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centersDiego Orsini0Luigi Gargiulo1Luciano Ibba2Ruggero Cascio Ingurgio3Mario Valenti4Chiara Perugini5Alessia Pacifico6Fabio S. Maramao7Pasquale Frascione8Antonio Costanzo9Alessandra Narcisi10Clinical Dermatology Unit - San Gallicano Dermatological Institute IRCCSDermatology Unit, IRCCS Humanitas Research HospitalDermatology Unit, IRCCS Humanitas Research HospitalDermatology Unit, IRCCS Humanitas Research HospitalDermatology Unit, IRCCS Humanitas Research HospitalDermatology Unit, IRCCS Humanitas Research HospitalClinical Dermatology Unit - San Gallicano Dermatological Institute IRCCSUOSD di Dermatologia, Fondazione Policlinico Tor Vergata, Università degli studi di Roma Tor VergataDermatology Oncology Unit– San Gallicano Dermatological Institute IRCCSDermatology Unit, IRCCS Humanitas Research HospitalDermatology Unit, IRCCS Humanitas Research HospitalThe management of plaque psoriasis that affects difficult-to-treat areas can be challenging. Biologics have become the treatment of choice for moderate-to-severe plaque psoriasis. However, there are limited data on their efficacy in difficult-to-treat sites (including scalp, palms/soles, nails and genitalia). We conducted a 52-week retrospective study to evaluate the effectiveness of risankizumab in 202 patients with moderate-to-severe involvement of at least one difficult-to-treat area. One hundred and sixty-five patients had scalp psoriasis, 21 had involvement of palms or soles, 72 were affected by genital psoriasis, and 50 patients reported the involvement of the fingernails. After one year of treatment, 97.58% of patients with scalp involvement, 95.28% of patients with palmoplantar psoriasis, 100% of patients with genital psoriasis and 82% of patients with nail involvement achieved a site-specific Physician’s Global Assessment of 0 or 1 (clear or almost clear). No serious adverse events were observed during the study. Our study supports the effectiveness of risankizumab in plaque psoriasis involving difficult-to-treat sites.http://dx.doi.org/10.1080/09546634.2023.2220849difficult areaspsoriasisreal-worldrisankizumab |
| spellingShingle | Diego Orsini Luigi Gargiulo Luciano Ibba Ruggero Cascio Ingurgio Mario Valenti Chiara Perugini Alessia Pacifico Fabio S. Maramao Pasquale Frascione Antonio Costanzo Alessandra Narcisi Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers Journal of Dermatological Treatment difficult areas psoriasis real-world risankizumab |
| title | Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers |
| title_full | Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers |
| title_fullStr | Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers |
| title_full_unstemmed | Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers |
| title_short | Effectiveness of risankizumab in plaque psoriasis with involvement of difficult-to-treat areas: a real-world experience from two referral centers |
| title_sort | effectiveness of risankizumab in plaque psoriasis with involvement of difficult to treat areas a real world experience from two referral centers |
| topic | difficult areas psoriasis real-world risankizumab |
| url | http://dx.doi.org/10.1080/09546634.2023.2220849 |
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