Essential role for a novel population of binucleated mammary epithelial cells in lactation
The main function of the mammary gland is to produce milk to sustain offspring. Here, the authors show that secretory alveolar cells in the lactating gland in several species are binucleated, which increases milk production, and that binucleation is regulated by Aurora kinase-A and Polo-like kinase-...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11400 |
| _version_ | 1823969151878692864 |
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| author | Anne C. Rios Nai Yang Fu Paul R. Jamieson Bhupinder Pal Lachlan Whitehead Kevin R. Nicholas Geoffrey J. Lindeman Jane E. Visvader |
| author_facet | Anne C. Rios Nai Yang Fu Paul R. Jamieson Bhupinder Pal Lachlan Whitehead Kevin R. Nicholas Geoffrey J. Lindeman Jane E. Visvader |
| author_sort | Anne C. Rios |
| collection | DOAJ |
| description | The main function of the mammary gland is to produce milk to sustain offspring. Here, the authors show that secretory alveolar cells in the lactating gland in several species are binucleated, which increases milk production, and that binucleation is regulated by Aurora kinase-A and Polo-like kinase-1. |
| first_indexed | 2024-12-17T18:52:57Z |
| format | Article |
| id | doaj.art-b9df98d6e85146f8b1f32303442dfa3f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T18:52:57Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b9df98d6e85146f8b1f32303442dfa3f2022-12-21T21:36:27ZengNature PortfolioNature Communications2041-17232016-04-017111210.1038/ncomms11400Essential role for a novel population of binucleated mammary epithelial cells in lactationAnne C. Rios0Nai Yang Fu1Paul R. Jamieson2Bhupinder Pal3Lachlan Whitehead4Kevin R. Nicholas5Geoffrey J. Lindeman6Jane E. Visvader7Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchStem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchStem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchStem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchSystems Biology and Personalised Medicine Division, Imaging Laboratory, The Walter and Eliza Hall Institute of Medical ResearchDepartment of Anatomy and Developmental Biology, Monash UniversityStem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchStem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchThe main function of the mammary gland is to produce milk to sustain offspring. Here, the authors show that secretory alveolar cells in the lactating gland in several species are binucleated, which increases milk production, and that binucleation is regulated by Aurora kinase-A and Polo-like kinase-1.https://doi.org/10.1038/ncomms11400 |
| spellingShingle | Anne C. Rios Nai Yang Fu Paul R. Jamieson Bhupinder Pal Lachlan Whitehead Kevin R. Nicholas Geoffrey J. Lindeman Jane E. Visvader Essential role for a novel population of binucleated mammary epithelial cells in lactation Nature Communications |
| title | Essential role for a novel population of binucleated mammary epithelial cells in lactation |
| title_full | Essential role for a novel population of binucleated mammary epithelial cells in lactation |
| title_fullStr | Essential role for a novel population of binucleated mammary epithelial cells in lactation |
| title_full_unstemmed | Essential role for a novel population of binucleated mammary epithelial cells in lactation |
| title_short | Essential role for a novel population of binucleated mammary epithelial cells in lactation |
| title_sort | essential role for a novel population of binucleated mammary epithelial cells in lactation |
| url | https://doi.org/10.1038/ncomms11400 |
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