Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancerResearch in context

Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancerResearch in context

Background: Most gastric cancers are diagnosed at an advanced or metastatic stage with poor prognosis and survival rate. Fatty acid 2-hydroxylase (FA2H) with high expression in stomach generates chiral (R)-2-hydroxy FAs ((R)-2-OHFAs) and regulates glucose utilization which is important for cell prol...

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Main Authors: Yizhou Yao, Xiaoqin Yang, Liang Sun, Shishuo Sun, Xiaoheng Huang, Diyuan Zhou, Tingting Li, Wei Zhang, Nada A. Abumrad, Xinguo Zhu, Songbing He, Xiong Su
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300726

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