Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study
Abstract Background Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the ef...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-019-0793-y |
| _version_ | 1819091415892754432 |
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| author | Xiao-feng Xiong Li Xu Li-li Fan De-yun Cheng Bi-xia Zheng |
| author_facet | Xiao-feng Xiong Li Xu Li-li Fan De-yun Cheng Bi-xia Zheng |
| author_sort | Xiao-feng Xiong |
| collection | DOAJ |
| description | Abstract Background Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis. Methods All patients treated with SEMSs from July 2003 to June 2016 were reviewed for symptomatic response, complications, and long-term outcomes. Results Total 131 stents were successfully deployed in 116 patients. Ninety-eight patients demonstrated clinical improvement after stent insertion (84.48%; 95% confidence interval [CI]: 77.89–91.07). Compared with uncovered stents, covered stents were associated with more sore throats complaints or chest pain (13.89% versus 28.81%, P = 0.036) and with higher incidences of major and minor granulation tissue formation and with recurrent stenosis (4.17% versus 15.25%, P = 0.029; 11.11% versus 37.29%, P < 0.0001 and 9.72% versus 28.81%, P = 0.005, respectively). Each covered and uncovered stent developing tissue hyperplasia required a median of 2 (range: 1–15) and 1(range: 1–7) fibrobronchoscope with electrocautery therapy, respectively. At follow-up (median: 1276 days; range: 2–4263), 68 patients had complete resolution, 15 remained under interventional treatment, 8 had bronchial occlusions, 7 underwent surgery, 14 were lost to follow-up, and 4 died of stent unrelated causes. Conclusion SEMS placement achieved most clinical improvement among patients in our study, if adequate endotracheal measures were used to address stent-related complications. The use of permanent SEMSs for benign tracheobronchial stenosis was effective and safe for the majority of patients in a long-term follow-up. Trial registration The study has been retrospectively registered in the China Clinical Trial Registry on October 21, 2018 (Registry ID: ChiCTR1800019024). |
| first_indexed | 2024-12-21T22:39:22Z |
| format | Article |
| id | doaj.art-b9e1064d80c04e8ab1ade7d69310ecc7 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-21T22:39:22Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-b9e1064d80c04e8ab1ade7d69310ecc72022-12-21T18:47:53ZengBMCBMC Pulmonary Medicine1471-24662019-02-0119111010.1186/s12890-019-0793-yLong-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective studyXiao-feng Xiong0Li Xu1Li-li Fan2De-yun Cheng3Bi-xia Zheng4Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityDepartment of Respiratory Medicine, Chengdu Third People’s HospitalAbstract Background Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis. Methods All patients treated with SEMSs from July 2003 to June 2016 were reviewed for symptomatic response, complications, and long-term outcomes. Results Total 131 stents were successfully deployed in 116 patients. Ninety-eight patients demonstrated clinical improvement after stent insertion (84.48%; 95% confidence interval [CI]: 77.89–91.07). Compared with uncovered stents, covered stents were associated with more sore throats complaints or chest pain (13.89% versus 28.81%, P = 0.036) and with higher incidences of major and minor granulation tissue formation and with recurrent stenosis (4.17% versus 15.25%, P = 0.029; 11.11% versus 37.29%, P < 0.0001 and 9.72% versus 28.81%, P = 0.005, respectively). Each covered and uncovered stent developing tissue hyperplasia required a median of 2 (range: 1–15) and 1(range: 1–7) fibrobronchoscope with electrocautery therapy, respectively. At follow-up (median: 1276 days; range: 2–4263), 68 patients had complete resolution, 15 remained under interventional treatment, 8 had bronchial occlusions, 7 underwent surgery, 14 were lost to follow-up, and 4 died of stent unrelated causes. Conclusion SEMS placement achieved most clinical improvement among patients in our study, if adequate endotracheal measures were used to address stent-related complications. The use of permanent SEMSs for benign tracheobronchial stenosis was effective and safe for the majority of patients in a long-term follow-up. Trial registration The study has been retrospectively registered in the China Clinical Trial Registry on October 21, 2018 (Registry ID: ChiCTR1800019024).http://link.springer.com/article/10.1186/s12890-019-0793-yBenign tracheobronchial stenosisSelf-expandable metallic stentsAirway stenting |
| spellingShingle | Xiao-feng Xiong Li Xu Li-li Fan De-yun Cheng Bi-xia Zheng Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study BMC Pulmonary Medicine Benign tracheobronchial stenosis Self-expandable metallic stents Airway stenting |
| title | Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study |
| title_full | Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study |
| title_fullStr | Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study |
| title_full_unstemmed | Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study |
| title_short | Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study |
| title_sort | long term follow up of self expandable metallic stents in benign tracheobronchial stenosis a retrospective study |
| topic | Benign tracheobronchial stenosis Self-expandable metallic stents Airway stenting |
| url | http://link.springer.com/article/10.1186/s12890-019-0793-y |
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