Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs
Melatonin, which is produced from tryptophan, exerts various biological functions, including the regulation of circadian rhythm, sedative agents, and antioxidant ability. Therefore, we conducted two experiments with early-weaned rats and pigs to investigate the antioxidant and sedative effects of me...
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| Format: | Article |
| Language: | English |
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Korean Society of Animal Sciences and Technology
2023-09-01
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| Series: | Journal of Animal Science and Technology |
| Subjects: | |
| Online Access: | http://www.ejast.org/archive/view_article?doi=10.5187/jast.2023.e44 |
| _version_ | 1827799513483444224 |
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| author | Min-Jin Kwak Kyeong Su Chae Jong Nam Kim Kwang-Youn Whang Younghoon Kim |
| author_facet | Min-Jin Kwak Kyeong Su Chae Jong Nam Kim Kwang-Youn Whang Younghoon Kim |
| author_sort | Min-Jin Kwak |
| collection | DOAJ |
| description | Melatonin, which is produced from tryptophan, exerts various biological functions, including the regulation of circadian rhythm, sedative agents, and antioxidant ability. Therefore, we conducted two experiments with early-weaned rats and pigs to investigate the antioxidant and sedative effects of melatonin. In the rat experiment, a total of 42 rats (21 days old) were used, and the antioxidant capacity was determined. Next, we used 120 early-weaned piglets (21 days old) to conduct a 5-week experiment to evaluate the reductive effect of melatonin on energy-wasting movement, including roaming and fight states. Dietary melatonin supplementation significantly improved growth in both rats and pigs compared to the control groups. Additionally, rats fed a melatonin-supplemented diet showed advanced antioxidant capacity with a decrease in hepatic malondialdehyde concentration compared to rats fed a basal diet. Moreover, dietary melatonin ingestion increased resting and feeding behaviors and reduced roaming and fight behaviors during Days 8–21 compared to the control diet group. Collectively, early weaned animals given dietary melatonin supplementation showed improved growth through upregulation of hepatic antioxidant capacity and minimization of energy-wasting behavior, including roaming and fight states, after pigs’ social hierarchy establishment. |
| first_indexed | 2024-03-11T19:53:40Z |
| format | Article |
| id | doaj.art-b9e2bfee20f24a929b33fde0d7c85c1b |
| institution | Directory Open Access Journal |
| issn | 2672-0191 2055-0391 |
| language | English |
| last_indexed | 2024-03-11T19:53:40Z |
| publishDate | 2023-09-01 |
| publisher | Korean Society of Animal Sciences and Technology |
| record_format | Article |
| series | Journal of Animal Science and Technology |
| spelling | doaj.art-b9e2bfee20f24a929b33fde0d7c85c1b2023-10-05T01:39:24ZengKorean Society of Animal Sciences and TechnologyJournal of Animal Science and Technology2672-01912055-03912023-09-016551053106410.5187/jast.2023.e44Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigsMin-Jin Kwak0Kyeong Su Chae1Jong Nam Kim2Kwang-Youn Whang3Younghoon Kim4Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, KoreaDivision of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, KoreaDepartment of Food Science & Nutrition, Dongseo University, Busan 47011, KoreaDivision of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, KoreaDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, KoreaMelatonin, which is produced from tryptophan, exerts various biological functions, including the regulation of circadian rhythm, sedative agents, and antioxidant ability. Therefore, we conducted two experiments with early-weaned rats and pigs to investigate the antioxidant and sedative effects of melatonin. In the rat experiment, a total of 42 rats (21 days old) were used, and the antioxidant capacity was determined. Next, we used 120 early-weaned piglets (21 days old) to conduct a 5-week experiment to evaluate the reductive effect of melatonin on energy-wasting movement, including roaming and fight states. Dietary melatonin supplementation significantly improved growth in both rats and pigs compared to the control groups. Additionally, rats fed a melatonin-supplemented diet showed advanced antioxidant capacity with a decrease in hepatic malondialdehyde concentration compared to rats fed a basal diet. Moreover, dietary melatonin ingestion increased resting and feeding behaviors and reduced roaming and fight behaviors during Days 8–21 compared to the control diet group. Collectively, early weaned animals given dietary melatonin supplementation showed improved growth through upregulation of hepatic antioxidant capacity and minimization of energy-wasting behavior, including roaming and fight states, after pigs’ social hierarchy establishment. http://www.ejast.org/archive/view_article?doi=10.5187/jast.2023.e44AntioxidantBehaviorGrowth performanceMelatoninPigRat |
| spellingShingle | Min-Jin Kwak Kyeong Su Chae Jong Nam Kim Kwang-Youn Whang Younghoon Kim Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs Journal of Animal Science and Technology Antioxidant Behavior Growth performance Melatonin Pig Rat |
| title | Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| title_full | Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| title_fullStr | Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| title_full_unstemmed | Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| title_short | Dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| title_sort | dietary effects of melatonin on growth performance by modulation of protein bioavailability and behavior in early weaned rats and pigs |
| topic | Antioxidant Behavior Growth performance Melatonin Pig Rat |
| url | http://www.ejast.org/archive/view_article?doi=10.5187/jast.2023.e44 |
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