COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor
: Purpose: The radiation recall phenomenon (RRP) is a rare and unexpected late complication of radiation therapy (RT). Although predominantly in the skin, RRP of the upper respiratory tract has also been reported. In general, RRP is caused by anticancer agents, and the COVID-19 vaccine has also be...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109422001543 |
| _version_ | 1811261319946436608 |
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| author | Shotaro Tatekawa, MD, PhD Shigenori Hoshino, MD, PhD Norihiko Takemoto, MD, PhD Michio Oda, RT, MS Yuichi Akino, PhD Kota Iwahori, MD, PhD Takero Hirata, MD, PhD Kazuhiko Hayashi, MD, PhD Keisuke Tamari, MD, PhD Yuji Seo, MD, PhD Fumiaki Isohashi, MD, PhD Shinichi Shimizu, MD, PhD Kazuhiko Ogawa, MD, PhD |
| author_facet | Shotaro Tatekawa, MD, PhD Shigenori Hoshino, MD, PhD Norihiko Takemoto, MD, PhD Michio Oda, RT, MS Yuichi Akino, PhD Kota Iwahori, MD, PhD Takero Hirata, MD, PhD Kazuhiko Hayashi, MD, PhD Keisuke Tamari, MD, PhD Yuji Seo, MD, PhD Fumiaki Isohashi, MD, PhD Shinichi Shimizu, MD, PhD Kazuhiko Ogawa, MD, PhD |
| author_sort | Shotaro Tatekawa, MD, PhD |
| collection | DOAJ |
| description | : Purpose: The radiation recall phenomenon (RRP) is a rare and unexpected late complication of radiation therapy (RT). Although predominantly in the skin, RRP of the upper respiratory tract has also been reported. In general, RRP is caused by anticancer agents, and the COVID-19 vaccine has also been reported to cause RRP in recent years. Methods and Materials: A 50-year-old woman who had received RT around the larynx 3 years prior and was receiving a docetaxel + ramucirumab (RAM) regimen experienced recurrent sore throat. The administration of RAM was discontinued after a gastroscopic examination revealed mucosal bleeding from around the larynx, which was thought to be RRP caused by RAM, a vascular endothelial growth factor inhibitor. Results: After the remission of the RRP, the patient received a COVID-19 vaccine (Pfizer-BioNTech). Five days later, the appearance of cough and recurrence of sore throat worsened with time, and marked stridor was observed. The patient was admitted, and steroid pulse therapy was administered for 3 days starting on day 18 after vaccination. On day 50 after vaccination, edema of the vocal cords improved. Conclusions: When administering COVID-19 vaccines, considering that these vaccines may cause RRP is important, because RRP can be fatal in patients with a history of RT in the laryngeal region and treated with vascular endothelial growth factor inhibitors. |
| first_indexed | 2024-04-12T19:02:27Z |
| format | Article |
| id | doaj.art-b9e33dc6c3c24b31b0069e434421de9f |
| institution | Directory Open Access Journal |
| issn | 2452-1094 |
| language | English |
| last_indexed | 2024-04-12T19:02:27Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj.art-b9e33dc6c3c24b31b0069e434421de9f2022-12-22T03:20:07ZengElsevierAdvances in Radiation Oncology2452-10942022-11-0176101048COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF InhibitorShotaro Tatekawa, MD, PhD0Shigenori Hoshino, MD, PhD1Norihiko Takemoto, MD, PhD2Michio Oda, RT, MS3Yuichi Akino, PhD4Kota Iwahori, MD, PhD5Takero Hirata, MD, PhD6Kazuhiko Hayashi, MD, PhD7Keisuke Tamari, MD, PhD8Yuji Seo, MD, PhD9Fumiaki Isohashi, MD, PhD10Shinichi Shimizu, MD, PhD11Kazuhiko Ogawa, MD, PhD12Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan; Corresponding author: Shotaro Tatekawa, MD, PhDDepartment of Respiratory Medicine, Saito Yukoukai Hospital, Osaka, JapanDepartment of Otorhinolaryngology, Saito Yukoukai Hospital, Osaka, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Medical Technology, Osaka University Hospital, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan : Purpose: The radiation recall phenomenon (RRP) is a rare and unexpected late complication of radiation therapy (RT). Although predominantly in the skin, RRP of the upper respiratory tract has also been reported. In general, RRP is caused by anticancer agents, and the COVID-19 vaccine has also been reported to cause RRP in recent years. Methods and Materials: A 50-year-old woman who had received RT around the larynx 3 years prior and was receiving a docetaxel + ramucirumab (RAM) regimen experienced recurrent sore throat. The administration of RAM was discontinued after a gastroscopic examination revealed mucosal bleeding from around the larynx, which was thought to be RRP caused by RAM, a vascular endothelial growth factor inhibitor. Results: After the remission of the RRP, the patient received a COVID-19 vaccine (Pfizer-BioNTech). Five days later, the appearance of cough and recurrence of sore throat worsened with time, and marked stridor was observed. The patient was admitted, and steroid pulse therapy was administered for 3 days starting on day 18 after vaccination. On day 50 after vaccination, edema of the vocal cords improved. Conclusions: When administering COVID-19 vaccines, considering that these vaccines may cause RRP is important, because RRP can be fatal in patients with a history of RT in the laryngeal region and treated with vascular endothelial growth factor inhibitors.http://www.sciencedirect.com/science/article/pii/S2452109422001543 |
| spellingShingle | Shotaro Tatekawa, MD, PhD Shigenori Hoshino, MD, PhD Norihiko Takemoto, MD, PhD Michio Oda, RT, MS Yuichi Akino, PhD Kota Iwahori, MD, PhD Takero Hirata, MD, PhD Kazuhiko Hayashi, MD, PhD Keisuke Tamari, MD, PhD Yuji Seo, MD, PhD Fumiaki Isohashi, MD, PhD Shinichi Shimizu, MD, PhD Kazuhiko Ogawa, MD, PhD COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor Advances in Radiation Oncology |
| title | COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor |
| title_full | COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor |
| title_fullStr | COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor |
| title_full_unstemmed | COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor |
| title_short | COVID-19 vaccine-induced Recurrence of the Radiation Recall Phenomenon in the Laryngeal Mucosa Due to a VEGF Inhibitor |
| title_sort | covid 19 vaccine induced recurrence of the radiation recall phenomenon in the laryngeal mucosa due to a vegf inhibitor |
| url | http://www.sciencedirect.com/science/article/pii/S2452109422001543 |
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