A natural marmoset model of genetic generalized epilepsy
Abstract Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Molecular Brain |
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| Online Access: | https://doi.org/10.1186/s13041-022-00901-2 |
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| author | Xiangyu Yang Zhitang Chen Ziying Wang Guang He Zhiqiang Li Yongyong Shi Neng Gong Binglei Zhao Yifang Kuang Eiki Takahashi Weidong Li |
| author_facet | Xiangyu Yang Zhitang Chen Ziying Wang Guang He Zhiqiang Li Yongyong Shi Neng Gong Binglei Zhao Yifang Kuang Eiki Takahashi Weidong Li |
| author_sort | Xiangyu Yang |
| collection | DOAJ |
| description | Abstract Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate models of epilepsy are required. The common marmoset (Callithrix jacchus) is a New World monkey that is widely used to study brain function. Here, we present a natural marmoset model of generalized epilepsy. In this unique marmoset family, generalized epilepsy was successfully induced by handling operations in some individuals. We mapped the marmoset family with handling-sensitive epilepsy and found that the epileptic phenotype can be inherited. These marmosets were more sensitive to the epilepsy inducers pentylenetetrazol. Using electrocorticogram (ECoG) recordings, we detected epileptiform discharge in marmosets with a history of seizures. In summary, we report a family of marmosets with generalized seizures induced by handling operations. This epileptic marmoset family provides insights to better understand the mechanism of generalized epilepsy and helps to develop new therapeutic methods. |
| first_indexed | 2024-12-13T13:28:58Z |
| format | Article |
| id | doaj.art-b9e40c75d51440d094505c689c59cf42 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-13T13:28:58Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-b9e40c75d51440d094505c689c59cf422022-12-21T23:44:13ZengBMCMolecular Brain1756-66062022-02-011511410.1186/s13041-022-00901-2A natural marmoset model of genetic generalized epilepsyXiangyu Yang0Zhitang Chen1Ziying Wang2Guang He3Zhiqiang Li4Yongyong Shi5Neng Gong6Binglei Zhao7Yifang Kuang8Eiki Takahashi9Weidong Li10Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityInstitute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong UniversityAbstract Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate models of epilepsy are required. The common marmoset (Callithrix jacchus) is a New World monkey that is widely used to study brain function. Here, we present a natural marmoset model of generalized epilepsy. In this unique marmoset family, generalized epilepsy was successfully induced by handling operations in some individuals. We mapped the marmoset family with handling-sensitive epilepsy and found that the epileptic phenotype can be inherited. These marmosets were more sensitive to the epilepsy inducers pentylenetetrazol. Using electrocorticogram (ECoG) recordings, we detected epileptiform discharge in marmosets with a history of seizures. In summary, we report a family of marmosets with generalized seizures induced by handling operations. This epileptic marmoset family provides insights to better understand the mechanism of generalized epilepsy and helps to develop new therapeutic methods.https://doi.org/10.1186/s13041-022-00901-2Natural marmoset modelNon-human primateGeneralized epilepsyECoG recordingBehavioral analysis |
| spellingShingle | Xiangyu Yang Zhitang Chen Ziying Wang Guang He Zhiqiang Li Yongyong Shi Neng Gong Binglei Zhao Yifang Kuang Eiki Takahashi Weidong Li A natural marmoset model of genetic generalized epilepsy Molecular Brain Natural marmoset model Non-human primate Generalized epilepsy ECoG recording Behavioral analysis |
| title | A natural marmoset model of genetic generalized epilepsy |
| title_full | A natural marmoset model of genetic generalized epilepsy |
| title_fullStr | A natural marmoset model of genetic generalized epilepsy |
| title_full_unstemmed | A natural marmoset model of genetic generalized epilepsy |
| title_short | A natural marmoset model of genetic generalized epilepsy |
| title_sort | natural marmoset model of genetic generalized epilepsy |
| topic | Natural marmoset model Non-human primate Generalized epilepsy ECoG recording Behavioral analysis |
| url | https://doi.org/10.1186/s13041-022-00901-2 |
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