Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner

Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner

Previous works from our group show that Semaphorin3B (Sema3B) is reduced in RA and plays a protective role in a mouse arthritis model. In turn, MerTK plays a protective function in murine arthritis models, is expressed by synovial tissue macrophages and is linked to remission in patients with RA. In...

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Bibliographic Details
Main Authors: Sara Martínez-Ramos, Carlos Rafael-Vidal, Beatriz Malvar-Fernández, Nair Pérez, Coral Mouriño, Sara García Pérez, Francisco J. Maceiras Pan, Carmen Conde, Jose María Pego-Reigosa, Samuel García
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
Semaphorin3B
macrophages
inflammation
MERTK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268144/full

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