Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients
β-Hydroxy-β-methylbutyrate (HMB) supplementation increases muscle and strength mass in some muscle-wasting disorders. Malnutrition and sarcopenia are often present in liver cirrhosis. We aimed to investigate the effects of oral HMB supplementation on changes in body composition and liver status in p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2344 |
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| author | Silvia Espina Alejandro Sanz-Paris Yolanda Gonzalez-Irazabal Patricia Pérez-Matute Fernando Andrade Beatriz Garcia-Rodriguez Christian Carpéné Alexia Zakaroff Vanesa Bernal-Monterde Javier Fuentes-Olmo Jose M. Arbones-Mainar |
| author_facet | Silvia Espina Alejandro Sanz-Paris Yolanda Gonzalez-Irazabal Patricia Pérez-Matute Fernando Andrade Beatriz Garcia-Rodriguez Christian Carpéné Alexia Zakaroff Vanesa Bernal-Monterde Javier Fuentes-Olmo Jose M. Arbones-Mainar |
| author_sort | Silvia Espina |
| collection | DOAJ |
| description | β-Hydroxy-β-methylbutyrate (HMB) supplementation increases muscle and strength mass in some muscle-wasting disorders. Malnutrition and sarcopenia are often present in liver cirrhosis. We aimed to investigate the effects of oral HMB supplementation on changes in body composition and liver status in patients with cirrhosis and malnutrition. In a randomized, controlled, double-blind trial, 43 individuals were randomized to receive twice a day and for 12 weeks an oral nutritional supplement (ONS) enriched with 1.5 g of calcium HMB per bottle or another supplement with similar composition devoid of HMB. Inclusion criteria were liver cirrhosis with at least one previous decompensation and clinical malnutrition. Liver function, plasma biochemistry analyses, and physical condition assessment were carried out at baseline, then after six and 12 weeks of supplementation. A total of 34 patients completed the clinical trial. An improvement in liver function and an increase in fat mass index were observed in both groups. None of the two ONS changed the fat-free mass. However, we observed an upward trend in handgrip strength and a downward trend in minimal hepatic encephalopathy in the HMB group. At the end of the trial and regardless of the supplement administered, fat mass content increased with no change in fat-free mass, while liver function scores and nutritional analytic markers also improved. |
| first_indexed | 2024-03-10T00:59:58Z |
| format | Article |
| id | doaj.art-b9e6aa00d2f74e7aa79012ee3d91f4c1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:59:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b9e6aa00d2f74e7aa79012ee3d91f4c12023-11-23T14:37:32ZengMDPI AGNutrients2072-66432022-06-011411234410.3390/nu14112344Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic PatientsSilvia Espina0Alejandro Sanz-Paris1Yolanda Gonzalez-Irazabal2Patricia Pérez-Matute3Fernando Andrade4Beatriz Garcia-Rodriguez5Christian Carpéné6Alexia Zakaroff7Vanesa Bernal-Monterde8Javier Fuentes-Olmo9Jose M. Arbones-Mainar10Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria (IIS) Aragon, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria (IIS) Aragon, 50009 Zaragoza, SpainInfectious Diseases, Microbiota and Metabolism Unit, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, SpainMetabolomics Platform, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, SpainClinical Biochemistry Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainInstitute of Metabolic and Cardiovascular Diseases, INSERM, UMR1297, Team Dinamix, 31432 Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases, INSERM, UMR1297, Team Dinamix, 31432 Toulouse, FranceGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainGastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria (IIS) Aragon, 50009 Zaragoza, Spainβ-Hydroxy-β-methylbutyrate (HMB) supplementation increases muscle and strength mass in some muscle-wasting disorders. Malnutrition and sarcopenia are often present in liver cirrhosis. We aimed to investigate the effects of oral HMB supplementation on changes in body composition and liver status in patients with cirrhosis and malnutrition. In a randomized, controlled, double-blind trial, 43 individuals were randomized to receive twice a day and for 12 weeks an oral nutritional supplement (ONS) enriched with 1.5 g of calcium HMB per bottle or another supplement with similar composition devoid of HMB. Inclusion criteria were liver cirrhosis with at least one previous decompensation and clinical malnutrition. Liver function, plasma biochemistry analyses, and physical condition assessment were carried out at baseline, then after six and 12 weeks of supplementation. A total of 34 patients completed the clinical trial. An improvement in liver function and an increase in fat mass index were observed in both groups. None of the two ONS changed the fat-free mass. However, we observed an upward trend in handgrip strength and a downward trend in minimal hepatic encephalopathy in the HMB group. At the end of the trial and regardless of the supplement administered, fat mass content increased with no change in fat-free mass, while liver function scores and nutritional analytic markers also improved.https://www.mdpi.com/2072-6643/14/11/2344cirrhosisliver function testnutritionHMBsupplement |
| spellingShingle | Silvia Espina Alejandro Sanz-Paris Yolanda Gonzalez-Irazabal Patricia Pérez-Matute Fernando Andrade Beatriz Garcia-Rodriguez Christian Carpéné Alexia Zakaroff Vanesa Bernal-Monterde Javier Fuentes-Olmo Jose M. Arbones-Mainar Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients Nutrients cirrhosis liver function test nutrition HMB supplement |
| title | Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients |
| title_full | Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients |
| title_fullStr | Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients |
| title_full_unstemmed | Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients |
| title_short | Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplementation in Malnourished Cirrhotic Patients |
| title_sort | randomized clinical trial effects of β hydroxy β methylbutyrate hmb enriched vs hmb free oral nutritional supplementation in malnourished cirrhotic patients |
| topic | cirrhosis liver function test nutrition HMB supplement |
| url | https://www.mdpi.com/2072-6643/14/11/2344 |
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