Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice

Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice

Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due to its deleterious dose-related side effects. We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardiotoxicity and physical dysfunction in vivo. To assess the shor...

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Bibliographic Details
Main Authors: Marielle Margier, Chisaka Kuehnemann, Nicolas Hulo, Jazmin Morales, Prasanna Vadhana Ashok Kumaar, Cecile Cros, Helene Cannelle, Julie Charmetant, Eric Verdin, Matthias Canault, Alessia Grozio
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
doxorubicin
nicotinamide mononucleotide
NAD+
cardiotoxicity
physical activity impairment
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/12/1/108

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