Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integ...
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2021-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/62997 |
| _version_ | 1811180635411185664 |
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| author | Christopher G Jacob Nguyen Thuy-Nhien Mayfong Mayxay Richard J Maude Huynh Hong Quang Bouasy Hongvanthong Viengxay Vanisaveth Thang Ngo Duc Huy Rekol Rob van der Pluijm Lorenz von Seidlein Rick Fairhurst François Nosten Md Amir Hossain Naomi Park Scott Goodwin Pascal Ringwald Keobouphaphone Chindavongsa Paul Newton Elizabeth Ashley Sonexay Phalivong Rapeephan Maude Rithea Leang Cheah Huch Le Thanh Dong Kim-Tuyen Nguyen Tran Minh Nhat Tran Tinh Hien Hoa Nguyen Nicole Zdrojewski Sara Canavati Abdullah Abu Sayeed Didar Uddin Caroline Buckee Caterina I Fanello Marie Onyamboko Thomas Peto Rupam Tripura Chanaki Amaratunga Aung Myint Thu Gilles Delmas Jordi Landier Daniel M Parker Nguyen Hoang Chau Dysoley Lek Seila Suon James Callery Podjanee Jittamala Borimas Hanboonkunupakarn Sasithon Pukrittayakamee Aung Pyae Phyo Frank Smithuis Khin Lin Myo Thant Tin Maung Hlaing Parthasarathi Satpathi Sanghamitra Satpathi Prativa K Behera Amar Tripura Subrata Baidya Neena Valecha Anupkumar R Anvikar Akhter Ul Islam Abul Faiz Chanon Kunasol Eleanor Drury Mihir Kekre Mozam Ali Katie Love Shavanthi Rajatileka Anna E Jeffreys Kate Rowlands Christina S Hubbart Mehul Dhorda Ranitha Vongpromek Namfon Kotanan Phrutsamon Wongnak Jacob Almagro Garcia Richard D Pearson Cristina V Ariani Thanat Chookajorn Cinzia Malangone T Nguyen Jim Stalker Ben Jeffery Jonathan Keatley Kimberly J Johnson Dawn Muddyman Xin Hui S Chan John Sillitoe Roberto Amato Victoria Simpson Sonia Gonçalves Kirk Rockett Nicholas P Day Arjen M Dondorp Dominic P Kwiatkowski Olivo Miotto |
| author_facet | Christopher G Jacob Nguyen Thuy-Nhien Mayfong Mayxay Richard J Maude Huynh Hong Quang Bouasy Hongvanthong Viengxay Vanisaveth Thang Ngo Duc Huy Rekol Rob van der Pluijm Lorenz von Seidlein Rick Fairhurst François Nosten Md Amir Hossain Naomi Park Scott Goodwin Pascal Ringwald Keobouphaphone Chindavongsa Paul Newton Elizabeth Ashley Sonexay Phalivong Rapeephan Maude Rithea Leang Cheah Huch Le Thanh Dong Kim-Tuyen Nguyen Tran Minh Nhat Tran Tinh Hien Hoa Nguyen Nicole Zdrojewski Sara Canavati Abdullah Abu Sayeed Didar Uddin Caroline Buckee Caterina I Fanello Marie Onyamboko Thomas Peto Rupam Tripura Chanaki Amaratunga Aung Myint Thu Gilles Delmas Jordi Landier Daniel M Parker Nguyen Hoang Chau Dysoley Lek Seila Suon James Callery Podjanee Jittamala Borimas Hanboonkunupakarn Sasithon Pukrittayakamee Aung Pyae Phyo Frank Smithuis Khin Lin Myo Thant Tin Maung Hlaing Parthasarathi Satpathi Sanghamitra Satpathi Prativa K Behera Amar Tripura Subrata Baidya Neena Valecha Anupkumar R Anvikar Akhter Ul Islam Abul Faiz Chanon Kunasol Eleanor Drury Mihir Kekre Mozam Ali Katie Love Shavanthi Rajatileka Anna E Jeffreys Kate Rowlands Christina S Hubbart Mehul Dhorda Ranitha Vongpromek Namfon Kotanan Phrutsamon Wongnak Jacob Almagro Garcia Richard D Pearson Cristina V Ariani Thanat Chookajorn Cinzia Malangone T Nguyen Jim Stalker Ben Jeffery Jonathan Keatley Kimberly J Johnson Dawn Muddyman Xin Hui S Chan John Sillitoe Roberto Amato Victoria Simpson Sonia Gonçalves Kirk Rockett Nicholas P Day Arjen M Dondorp Dominic P Kwiatkowski Olivo Miotto |
| author_sort | Christopher G Jacob |
| collection | DOAJ |
| description | Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.
Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.
Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.
Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.
Funding: The GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases. |
| first_indexed | 2024-04-11T09:06:29Z |
| format | Article |
| id | doaj.art-b9ea0c3fbc464263ad577b4b2da14f13 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:06:29Z |
| publishDate | 2021-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-b9ea0c3fbc464263ad577b4b2da14f132022-12-22T04:32:37ZengeLife Sciences Publications LtdeLife2050-084X2021-08-011010.7554/eLife.62997Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and eliminationChristopher G Jacob0Nguyen Thuy-Nhien1Mayfong Mayxay2Richard J Maude3https://orcid.org/0000-0002-5355-0562Huynh Hong Quang4Bouasy Hongvanthong5Viengxay Vanisaveth6Thang Ngo Duc7Huy Rekol8Rob van der Pluijm9Lorenz von Seidlein10Rick Fairhurst11François Nosten12https://orcid.org/0000-0002-7951-0745Md Amir Hossain13Naomi Park14Scott Goodwin15Pascal Ringwald16Keobouphaphone Chindavongsa17Paul Newton18Elizabeth Ashley19Sonexay Phalivong20Rapeephan Maude21Rithea Leang22Cheah Huch23Le Thanh Dong24Kim-Tuyen Nguyen25Tran Minh Nhat26https://orcid.org/0000-0002-9500-8341Tran Tinh Hien27Hoa Nguyen28Nicole Zdrojewski29Sara Canavati30Abdullah Abu Sayeed31Didar Uddin32Caroline Buckee33https://orcid.org/0000-0002-8386-5899Caterina I Fanello34Marie Onyamboko35Thomas Peto36Rupam Tripura37Chanaki Amaratunga38Aung Myint Thu39Gilles Delmas40Jordi Landier41https://orcid.org/0000-0001-8619-9775Daniel M Parker42Nguyen Hoang Chau43Dysoley Lek44Seila Suon45James Callery46https://orcid.org/0000-0002-3218-2166Podjanee Jittamala47Borimas Hanboonkunupakarn48Sasithon Pukrittayakamee49Aung Pyae Phyo50Frank Smithuis51https://orcid.org/0000-0002-4704-9915Khin Lin52Myo Thant53Tin Maung Hlaing54Parthasarathi Satpathi55Sanghamitra Satpathi56Prativa K Behera57Amar Tripura58Subrata Baidya59Neena Valecha60Anupkumar R Anvikar61Akhter Ul Islam62Abul Faiz63Chanon Kunasol64Eleanor Drury65Mihir Kekre66Mozam Ali67Katie Love68Shavanthi Rajatileka69Anna E Jeffreys70Kate Rowlands71Christina S Hubbart72https://orcid.org/0000-0001-9576-9581Mehul Dhorda73Ranitha Vongpromek74Namfon Kotanan75Phrutsamon Wongnak76Jacob Almagro Garcia77Richard D Pearson78https://orcid.org/0000-0002-7386-3566Cristina V Ariani79Thanat Chookajorn80Cinzia Malangone81T Nguyen82Jim Stalker83Ben Jeffery84Jonathan Keatley85Kimberly J Johnson86Dawn Muddyman87Xin Hui S Chan88John Sillitoe89Roberto Amato90Victoria Simpson91Sonia Gonçalves92Kirk Rockett93https://orcid.org/0000-0002-6369-9299Nicholas P Day94https://orcid.org/0000-0003-2309-1171Arjen M Dondorp95https://orcid.org/0000-0001-5190-2395Dominic P Kwiatkowski96Olivo Miotto97https://orcid.org/0000-0001-8060-6771Wellcome Sanger Institute, Hinxton, United KingdomOxford University Clinical Research Unit, Ho Chi Minh City, Viet NamLao-Oxford-Mahosot Hospital-Wellcome Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic; Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United KingdomCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Harvard TH Chan School of Public Health, Harvard University, Boston, United StatesInstitute of Malariology, Parasitology and Entomology (IMPE-QN), Quy Nhon, Viet NamCentre of Malariology, Parasitology, and Entomology, Vientiane, Lao People's Democratic RepublicCentre of Malariology, Parasitology, and Entomology, Vientiane, Lao People's Democratic RepublicNational Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Viet NamNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, CambodiaCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United StatesCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Shoklo Malaria Research Unit, Mae Sot, ThailandChittagong Medical College Hospital, Chittagong, BangladeshWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWorld Health Organization, Geneva, SwitzerlandCentre of Malariology, Parasitology, and Entomology, Vientiane, Lao People's Democratic RepublicLao-Oxford-Mahosot Hospital-Wellcome Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandLao-Oxford-Mahosot Hospital-Wellcome Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United KingdomLao-Oxford-Mahosot Hospital-Wellcome Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic RepublicMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, CambodiaNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, CambodiaInstitute of Malariology, Parasitology and Entomology (IMPEHCM), Ho Chi Minh City, Viet NamOxford University Clinical Research Unit, Ho Chi Minh City, Viet NamOxford University Clinical Research Unit, Ho Chi Minh City, Viet NamOxford University Clinical Research Unit, Ho Chi Minh City, Viet NamVysnova Partners Inc, Hanoi, Viet NamVysnova Partners Inc, Hanoi, Viet NamVysnova Partners Inc, Hanoi, Viet NamChittagong Medical College Hospital, Chittagong, BangladeshMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandHarvard TH Chan School of Public Health, Harvard University, Boston, United StatesCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandKinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the CongoCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United StatesCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Shoklo Malaria Research Unit, Mae Sot, ThailandCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Shoklo Malaria Research Unit, Mae Sot, ThailandShoklo Malaria Research Unit, Mae Sot, Thailand; Aix-Marseille Université, INSERM, IRD, SESSTIM, Aix Marseille Institute of Public Health, ISSPAM, Marseille, FranceShoklo Malaria Research Unit, Mae Sot, Thailand; Susan and Henry Samueli College of Health Sciences, University of California, Irvine, Irvine, United StatesOxford University Clinical Research Unit, Ho Chi Minh City, Viet NamNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, CambodiaNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, CambodiaCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandFaculty of Tropical Medicine, Mahidol University, Bangkok, ThailandFaculty of Tropical Medicine, Mahidol University, Bangkok, ThailandFaculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; The Royal Society of Thailand, Bangkok, ThailandCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Myanmar-Oxford Clinical Research Unit, Yangon, MyanmarCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Myanmar-Oxford Clinical Research Unit, Yangon, MyanmarDepartment of Medical Research, Pyin Oo Lwin, MyanmarDefence Services Medical Research Centre, Yangon, MyanmarDefence Services Medical Research Centre, Yangon, MyanmarMidnapore Medical College, Midnapur, IndiaIspat General Hospital, Rourkela, IndiaIspat General Hospital, Rourkela, IndiaAgartala Medical College, Agartala, IndiaAgartala Medical College, Agartala, IndiaNational Institute of Malaria Research, Indian Council of Medical Research, New Delhi, IndiaNational Institute of Malaria Research, Indian Council of Medical Research, New Delhi, IndiaRamu Upazila Health Complex, Cox's Bazar, BangladeshMalaria Research Group and Dev Care Foundation, Dhaka, BangladeshMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Worldwide Antimalarial Resistance Network (WWARN), Asia Regional Centre, Bangkok, ThailandMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Worldwide Antimalarial Resistance Network (WWARN), Asia Regional Centre, Bangkok, ThailandFaculty of Tropical Medicine, Mahidol University, Bangkok, ThailandMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandMRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United KingdomFaculty of Tropical Medicine, Mahidol University, Bangkok, ThailandWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomMRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United KingdomCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandCentre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandWellcome Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United KingdomBackground: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures. Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs. Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs. Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community. Funding: The GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases.https://elifesciences.org/articles/62997malariagenetic surveillancedrug resistanceasia |
| spellingShingle | Christopher G Jacob Nguyen Thuy-Nhien Mayfong Mayxay Richard J Maude Huynh Hong Quang Bouasy Hongvanthong Viengxay Vanisaveth Thang Ngo Duc Huy Rekol Rob van der Pluijm Lorenz von Seidlein Rick Fairhurst François Nosten Md Amir Hossain Naomi Park Scott Goodwin Pascal Ringwald Keobouphaphone Chindavongsa Paul Newton Elizabeth Ashley Sonexay Phalivong Rapeephan Maude Rithea Leang Cheah Huch Le Thanh Dong Kim-Tuyen Nguyen Tran Minh Nhat Tran Tinh Hien Hoa Nguyen Nicole Zdrojewski Sara Canavati Abdullah Abu Sayeed Didar Uddin Caroline Buckee Caterina I Fanello Marie Onyamboko Thomas Peto Rupam Tripura Chanaki Amaratunga Aung Myint Thu Gilles Delmas Jordi Landier Daniel M Parker Nguyen Hoang Chau Dysoley Lek Seila Suon James Callery Podjanee Jittamala Borimas Hanboonkunupakarn Sasithon Pukrittayakamee Aung Pyae Phyo Frank Smithuis Khin Lin Myo Thant Tin Maung Hlaing Parthasarathi Satpathi Sanghamitra Satpathi Prativa K Behera Amar Tripura Subrata Baidya Neena Valecha Anupkumar R Anvikar Akhter Ul Islam Abul Faiz Chanon Kunasol Eleanor Drury Mihir Kekre Mozam Ali Katie Love Shavanthi Rajatileka Anna E Jeffreys Kate Rowlands Christina S Hubbart Mehul Dhorda Ranitha Vongpromek Namfon Kotanan Phrutsamon Wongnak Jacob Almagro Garcia Richard D Pearson Cristina V Ariani Thanat Chookajorn Cinzia Malangone T Nguyen Jim Stalker Ben Jeffery Jonathan Keatley Kimberly J Johnson Dawn Muddyman Xin Hui S Chan John Sillitoe Roberto Amato Victoria Simpson Sonia Gonçalves Kirk Rockett Nicholas P Day Arjen M Dondorp Dominic P Kwiatkowski Olivo Miotto Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination eLife malaria genetic surveillance drug resistance asia |
| title | Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination |
| title_full | Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination |
| title_fullStr | Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination |
| title_full_unstemmed | Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination |
| title_short | Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination |
| title_sort | genetic surveillance in the greater mekong subregion and south asia to support malaria control and elimination |
| topic | malaria genetic surveillance drug resistance asia |
| url | https://elifesciences.org/articles/62997 |
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