Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.

Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.

<h4>Background</h4>Nitrous oxide has shown potentially as an efficacious intervention for treatment-resistant depression, yet there remains insufficient evidence pertaining to repeated administration of nitrous oxide over time and active placebo-controlled studies with optimal blinding....

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Bibliographic Details
Main Authors: Karim S Ladha, Jiwon Lee, Gabriella F Mattina, Janneth Pazmino-Canizares, Duminda N Wijeysundera, Fatemeh Gholamali Nezhad, Kaylyssa Philip, Vanessa K Tassone, Fathima Adamsahib, Venkat Bhat, SMILE Study Investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297330&type=printable

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