Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women
Abstract Background Although many environmental factors play an important role in bone mass density (BMD) variation, genetic influences account for 60–85% of individual variance. The aim of this study was to find the interaction between some dietary ingredients, vitamin D, estrogen, and obesity poly...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Journal of Genetic Engineering and Biotechnology |
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| Online Access: | https://doi.org/10.1186/s43141-021-00127-0 |
| _version_ | 1797203186667225088 |
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| author | Nayera E. Hassan Salwa M. El Shebini Sahar A. El-Masry Nihad H. Ahmed Ghada Nour Eldeen Enas A. Rasheed Manal M. Aly Khhadija M. Alian Mahmoud A S. Afify Aya Khalil |
| author_facet | Nayera E. Hassan Salwa M. El Shebini Sahar A. El-Masry Nihad H. Ahmed Ghada Nour Eldeen Enas A. Rasheed Manal M. Aly Khhadija M. Alian Mahmoud A S. Afify Aya Khalil |
| author_sort | Nayera E. Hassan |
| collection | DOAJ |
| description | Abstract Background Although many environmental factors play an important role in bone mass density (BMD) variation, genetic influences account for 60–85% of individual variance. The aim of this study was to find the interaction between some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes, among a sample of obese Egyptian women. This was a cross sectional study included 97 women (aged 25–60 years). Data on anthropometry, dietary intake, BMD, biochemical, and genetic analyses were collected. Results Osteoporosis was high among women had dominant Taq1 vitamin D receptor gene while osteoporosis was less common among the homozygous Apa1 receptor gene women. Both genes in their two forms did not show any effect on serum vitamin D. Heterozygous types of osteoporotic women carried both genes revealed a slight but significant decrease in level of serum calcium. Xba1 estrogen receptor gene was identified only in a homozygous type while the heterozygous Pvu11 estrogen receptors gene has been identified among both osteoporotic and non-osteoporotic women, this gene was associated with higher BMI in both groups compared to the homozygous receptor gene. Mutant types of genotype FTOrs99 and FTOrs80 obesity receptors genes were less common (4.44%, 11%) among participants. Both of these genes were associated with the highest value of BMI and caloric daily intake, fat, and saturated fatty acid that were more prominent among osteoporotic women. Conclusion There is significant association between vitamin D, estrogen, obesity receptors genes, special nutrients, and osteoporosis. Increased BMI, calories, and fat intake lead to rise of genetic predisposition and susceptibility to osteoporosis. |
| first_indexed | 2024-04-24T08:15:20Z |
| format | Article |
| id | doaj.art-b9ea966b8ac044fdb3c2645db15d3e61 |
| institution | Directory Open Access Journal |
| issn | 2090-5920 |
| language | English |
| last_indexed | 2024-04-24T08:15:20Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Genetic Engineering and Biotechnology |
| spelling | doaj.art-b9ea966b8ac044fdb3c2645db15d3e612024-04-17T04:15:31ZengElsevierJournal of Genetic Engineering and Biotechnology2090-59202021-02-011911910.1186/s43141-021-00127-0Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian womenNayera E. Hassan0Salwa M. El Shebini1Sahar A. El-Masry2Nihad H. Ahmed3Ghada Nour Eldeen4Enas A. Rasheed5Manal M. Aly6Khhadija M. Alian7Mahmoud A S. Afify8Aya Khalil9Biological Anthropology Department, Medical Research Division, National Research CentreNutrition and Food ScienceDepartment, National Research CentreBiological Anthropology Department, Medical Research Division, National Research CentreNutrition and Food ScienceDepartment, National Research CentreMolecular Genetics and Enzymology Department, National Research CentreClinical and Chemical Pathology Department, Medical Research Division, National Research CentreBiological Anthropology Department, Medical Research Division, National Research CentreBiological Anthropology Department, Medical Research Division, National Research CentreBiological Anthropology Department, Medical Research Division, National Research CentreBiological Anthropology Department, Medical Research Division, National Research CentreAbstract Background Although many environmental factors play an important role in bone mass density (BMD) variation, genetic influences account for 60–85% of individual variance. The aim of this study was to find the interaction between some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes, among a sample of obese Egyptian women. This was a cross sectional study included 97 women (aged 25–60 years). Data on anthropometry, dietary intake, BMD, biochemical, and genetic analyses were collected. Results Osteoporosis was high among women had dominant Taq1 vitamin D receptor gene while osteoporosis was less common among the homozygous Apa1 receptor gene women. Both genes in their two forms did not show any effect on serum vitamin D. Heterozygous types of osteoporotic women carried both genes revealed a slight but significant decrease in level of serum calcium. Xba1 estrogen receptor gene was identified only in a homozygous type while the heterozygous Pvu11 estrogen receptors gene has been identified among both osteoporotic and non-osteoporotic women, this gene was associated with higher BMI in both groups compared to the homozygous receptor gene. Mutant types of genotype FTOrs99 and FTOrs80 obesity receptors genes were less common (4.44%, 11%) among participants. Both of these genes were associated with the highest value of BMI and caloric daily intake, fat, and saturated fatty acid that were more prominent among osteoporotic women. Conclusion There is significant association between vitamin D, estrogen, obesity receptors genes, special nutrients, and osteoporosis. Increased BMI, calories, and fat intake lead to rise of genetic predisposition and susceptibility to osteoporosis.https://doi.org/10.1186/s43141-021-00127-0OsteoporosisVitamin D receptors genesEstrogens receptors genesObesity receptors genesDietary intake |
| spellingShingle | Nayera E. Hassan Salwa M. El Shebini Sahar A. El-Masry Nihad H. Ahmed Ghada Nour Eldeen Enas A. Rasheed Manal M. Aly Khhadija M. Alian Mahmoud A S. Afify Aya Khalil Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women Journal of Genetic Engineering and Biotechnology Osteoporosis Vitamin D receptors genes Estrogens receptors genes Obesity receptors genes Dietary intake |
| title | Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women |
| title_full | Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women |
| title_fullStr | Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women |
| title_full_unstemmed | Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women |
| title_short | Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women |
| title_sort | association of some dietary ingredients vitamin d estrogen and obesity polymorphic receptor genes with bone mineral density in a sample of obese egyptian women |
| topic | Osteoporosis Vitamin D receptors genes Estrogens receptors genes Obesity receptors genes Dietary intake |
| url | https://doi.org/10.1186/s43141-021-00127-0 |
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