Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels
This study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochlori...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.826971/full |
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| author | Ming Sun Ming Sun Lidi Cheng Lidi Cheng Zexian Xu Zexian Xu Liqiang Chen Liqiang Chen Liqiang Chen Yanshan Liu Yanshan Liu Yanshan Liu Yaoxiang Xu Yaoxiang Xu Dongyang Zhou Dongyang Zhou Xiuxiu Zhang Xiuxiu Zhang Qihui Zhou Qihui Zhou Qihui Zhou Jian Sun Jian Sun Jian Sun Jian Sun |
| author_facet | Ming Sun Ming Sun Lidi Cheng Lidi Cheng Zexian Xu Zexian Xu Liqiang Chen Liqiang Chen Liqiang Chen Yanshan Liu Yanshan Liu Yanshan Liu Yaoxiang Xu Yaoxiang Xu Dongyang Zhou Dongyang Zhou Xiuxiu Zhang Xiuxiu Zhang Qihui Zhou Qihui Zhou Qihui Zhou Jian Sun Jian Sun Jian Sun Jian Sun |
| author_sort | Ming Sun |
| collection | DOAJ |
| description | This study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochloride (Van), and Van/SBA-15 was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Brunauer–Emmett–Teller (BET), and Barrett–Joyner–Halenda (BJH). The characterization results confirm that Van is loaded in SBA-15 successfully. Van/SBA-15/CS-GP-SA is constructed by encapsulating Van/SBA-15 in chitosan–sodium glycerophosphate–sodium alginate hydrogel (CS-GP-SA). The microstructures, sustained-release ability, biocompatibility, and antibacterial properties of Van/SBA-15/CS-GP-SA were systematically studied. Van/SBA-15/CS-GP-SA is found to have promising sustained-release ability, outstanding biocompatibility, and excellent antibacterial properties. This study provides new ideas for the management of infectious jaw defects. |
| first_indexed | 2024-12-13T13:25:34Z |
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| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-13T13:25:34Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b9eac164183340caa8defe87955fae172022-12-21T23:44:19ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-02-011010.3389/fbioe.2022.826971826971Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite HydrogelsMing Sun0Ming Sun1Lidi Cheng2Lidi Cheng3Zexian Xu4Zexian Xu5Liqiang Chen6Liqiang Chen7Liqiang Chen8Yanshan Liu9Yanshan Liu10Yanshan Liu11Yaoxiang Xu12Yaoxiang Xu13Dongyang Zhou14Dongyang Zhou15Xiuxiu Zhang16Xiuxiu Zhang17Qihui Zhou18Qihui Zhou19Qihui Zhou20Jian Sun21Jian Sun22Jian Sun23Jian Sun24The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology of Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaShandong Provincial Key Laboratory of Digital Medicine and Computer‐Assisted Surgery, Qingdao, ChinaThis study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochloride (Van), and Van/SBA-15 was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Brunauer–Emmett–Teller (BET), and Barrett–Joyner–Halenda (BJH). The characterization results confirm that Van is loaded in SBA-15 successfully. Van/SBA-15/CS-GP-SA is constructed by encapsulating Van/SBA-15 in chitosan–sodium glycerophosphate–sodium alginate hydrogel (CS-GP-SA). The microstructures, sustained-release ability, biocompatibility, and antibacterial properties of Van/SBA-15/CS-GP-SA were systematically studied. Van/SBA-15/CS-GP-SA is found to have promising sustained-release ability, outstanding biocompatibility, and excellent antibacterial properties. This study provides new ideas for the management of infectious jaw defects.https://www.frontiersin.org/articles/10.3389/fbioe.2022.826971/fullbiomaterialshydrogeldrug deliverybiocompatibilityantibacterial |
| spellingShingle | Ming Sun Ming Sun Lidi Cheng Lidi Cheng Zexian Xu Zexian Xu Liqiang Chen Liqiang Chen Liqiang Chen Yanshan Liu Yanshan Liu Yanshan Liu Yaoxiang Xu Yaoxiang Xu Dongyang Zhou Dongyang Zhou Xiuxiu Zhang Xiuxiu Zhang Qihui Zhou Qihui Zhou Qihui Zhou Jian Sun Jian Sun Jian Sun Jian Sun Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels Frontiers in Bioengineering and Biotechnology biomaterials hydrogel drug delivery biocompatibility antibacterial |
| title | Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels |
| title_full | Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels |
| title_fullStr | Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels |
| title_full_unstemmed | Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels |
| title_short | Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels |
| title_sort | preparation and characterization of vancomycin hydrochloride loaded mesoporous silica composite hydrogels |
| topic | biomaterials hydrogel drug delivery biocompatibility antibacterial |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.826971/full |
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