Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.
Forkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-11-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18998771/?tool=EBI |
| _version_ | 1818362570597203968 |
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| author | Kristian G Andersen Tracey Butcher Alexander G Betz |
| author_facet | Kristian G Andersen Tracey Butcher Alexander G Betz |
| author_sort | Kristian G Andersen |
| collection | DOAJ |
| description | Forkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and transplant rejection. Here, we show that adoptive transfer of polyclonal, wild-type T cells transduced with an inducible form of Foxp3 (iFoxp3) can be used to suppress immune responses on demand. In contrast to Foxp3-transduced cells, iFoxp3-transduced cells home "correctly" into secondary lymphoid organs, where they expand and participate in immune responses. Upon induction of iFoxp3, the cells assume regulatory T cell phenotype and start to suppress the response they initially partook in without causing systemic immunosuppression. We used this approach to suppress collagen-induced arthritis, in which conventional Foxp3-transduced cells failed to show any effect. This provides us with a generally applicable strategy to specifically halt immune responses on demand without prior knowledge of the antigens involved. |
| first_indexed | 2024-12-13T21:34:41Z |
| format | Article |
| id | doaj.art-b9edc65bd69942cdba3181bac6d9440b |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-13T21:34:41Z |
| publishDate | 2008-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-b9edc65bd69942cdba3181bac6d9440b2022-12-21T23:30:43ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852008-11-01611e27610.1371/journal.pbio.0060276Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.Kristian G AndersenTracey ButcherAlexander G BetzForkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and transplant rejection. Here, we show that adoptive transfer of polyclonal, wild-type T cells transduced with an inducible form of Foxp3 (iFoxp3) can be used to suppress immune responses on demand. In contrast to Foxp3-transduced cells, iFoxp3-transduced cells home "correctly" into secondary lymphoid organs, where they expand and participate in immune responses. Upon induction of iFoxp3, the cells assume regulatory T cell phenotype and start to suppress the response they initially partook in without causing systemic immunosuppression. We used this approach to suppress collagen-induced arthritis, in which conventional Foxp3-transduced cells failed to show any effect. This provides us with a generally applicable strategy to specifically halt immune responses on demand without prior knowledge of the antigens involved.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18998771/?tool=EBI |
| spellingShingle | Kristian G Andersen Tracey Butcher Alexander G Betz Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. PLoS Biology |
| title | Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. |
| title_full | Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. |
| title_fullStr | Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. |
| title_full_unstemmed | Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. |
| title_short | Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. |
| title_sort | specific immunosuppression with inducible foxp3 transduced polyclonal t cells |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18998771/?tool=EBI |
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