The PD-1/PD-L1 Checkpoint in Normal Germinal Centers and Diffuse Large B-Cell Lymphomas

The PD-1/PD-L1 Checkpoint in Normal Germinal Centers and Diffuse Large B-Cell Lymphomas

Besides a recognized role of PD-1/PD-L1 checkpoint in anti-tumour immune evasion, there is accumulating evidence that PD-1/PD-L1 interactions between B and T cells also play an important role in normal germinal center (GC) reactions. Even when smaller in number, T follicular helper cells (T<sub&g...

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Bibliographic Details
Main Authors: Marcos Garcia-Lacarte, Sara C. Grijalba, Javier Melchor, Adrián Arnaiz-Leché, Sergio Roa
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
immune checkpoint
germinal center
lymphoma
GC B cells
T follicular helper cells
T follicular regulatory cells
Online Access:https://www.mdpi.com/2072-6694/13/18/4683

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