Tumor extrachromosomal DNA: Biogenesis and recent advances in the field

Tumor extrachromosomal DNA: Biogenesis and recent advances in the field

Extrachromosomal DNA (ecDNA) is a self-replicating circular DNA originating from the chromosomal genome and exists outside the chromosome. It contains specific gene sequences and non-coding regions that regulate transcription. Recent studies have demonstrated that ecDNA is present in various maligna...

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Bibliographic Details
Main Authors: Haomin Wu, Shiqi Liu, Di Wu, Haonan Zhou, Gang Wu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
ecDNA，tumor heterogeneity，drug resistance，biomarkers，genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004724

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