Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2

Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2

Human Fe(II)/α-ketoglutarate-dependent dioxygenase ABH2 plays a crucial role in the direct reversal repair of nonbulky alkyl lesions in DNA nucleobases, e.g., N<sup>1</sup>-methyladenine (m<sup>1</sup>A), N<sup>3</sup>-methylcytosine (m<sup>3</sup>C),...

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Bibliographic Details
Main Authors:	Anastasiia T. Davletgildeeva, Timofey E. Tyugashev, Mingxing Zhao, Nikita A. Kuznetsov, Alexander A. Ishchenko, Murat Saparbaev, Aleksandra A. Kuznetsova
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	Cells
Subjects:	DNA repair DNA dioxygenase ABH2 DNA methylation conformational dynamics fluorescent spectroscopy presteady-state kinetics
Online Access:	https://www.mdpi.com/2073-4409/12/14/1839

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