Etiology and failure analysis of anterior lamellar keratoplasty
AIM: To analyze indications and reasons for failure of anterior lamellar keratoplasty (ALK). METHODS: The clinical records were retrospectively reviewed. Main outcome measures included indications for ALK and reasons for failure of ALK. RESULTS: A total of 434 patients (462 eyes) were treated with...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-05-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ijo.cn/en_publish/2018/5/20180511.pdf |
| _version_ | 1828160997287788544 |
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| author | Zhen Wang Xiao-Jun Tan Hua-Lei Zhai Jun Cheng Yan Gao Li-Xin Xie |
| author_facet | Zhen Wang Xiao-Jun Tan Hua-Lei Zhai Jun Cheng Yan Gao Li-Xin Xie |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | AIM: To analyze indications and reasons for failure of anterior lamellar keratoplasty (ALK).
METHODS: The clinical records were retrospectively reviewed. Main outcome measures included indications for ALK and reasons for failure of ALK.
RESULTS: A total of 434 patients (462 eyes) were treated with ALK at Qingdao Eye Hospital, Shandong Eye Institute from June 1, 2009 to May 31, 2016. The main indications were infectious keratitis (33.3%), keratoconus (23.6%), corneal dystrophy and degeneration (9.8%), Mooren’s ulcer (8.4%), corneal neoplasm (7.8%), viral keratitis (6.5%) and regrafting (3.7%). Fungal keratitis accounted for 73.4% in the infectious keratitis cases. ALKs were failed in 36 patients, with the major causes being recurrence of primary diseases (63.9%). The leading causes of graft failure was Mooren’s ulcer (36.1%), followed by infectious keratitis (30.6%). Recurrence of fungal keratitis accounted for 81.8% in the failed cases after ALK for infectious keratitis cases.
CONCLUSION: Infectious keratitis and keratoconus are the main indications for ALK, of which fungal keratitis was the major cause of corneal infections. Recurrence of primary disease is the main reason of graft failure after ALK, in which the main primary diseases associated with graft failure are Mooren’s ulcer and fungal keratitis. |
| first_indexed | 2024-04-12T00:30:12Z |
| format | Article |
| id | doaj.art-b9f641e01a23476fb8970643f5ef87cf |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T00:30:12Z |
| publishDate | 2018-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-b9f641e01a23476fb8970643f5ef87cf2022-12-22T03:55:21ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-05-0111578679010.18240/ijo.2018.05.11Etiology and failure analysis of anterior lamellar keratoplastyZhen Wang0Xiao-Jun Tan1Hua-Lei Zhai2Jun Cheng3Yan Gao4Li-Xin Xie5Qingdao University Medical College, Qingdao 266071, Shandong Province, China; Affiliated Yidu Central Hospital of Weifang Medical College, Weifang 262500, Shandong Province, ChinaAffiliated Yidu Central Hospital of Weifang Medical College, Weifang 262500, Shandong Province, ChinaQingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaQingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaQingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaQingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaAIM: To analyze indications and reasons for failure of anterior lamellar keratoplasty (ALK). METHODS: The clinical records were retrospectively reviewed. Main outcome measures included indications for ALK and reasons for failure of ALK. RESULTS: A total of 434 patients (462 eyes) were treated with ALK at Qingdao Eye Hospital, Shandong Eye Institute from June 1, 2009 to May 31, 2016. The main indications were infectious keratitis (33.3%), keratoconus (23.6%), corneal dystrophy and degeneration (9.8%), Mooren’s ulcer (8.4%), corneal neoplasm (7.8%), viral keratitis (6.5%) and regrafting (3.7%). Fungal keratitis accounted for 73.4% in the infectious keratitis cases. ALKs were failed in 36 patients, with the major causes being recurrence of primary diseases (63.9%). The leading causes of graft failure was Mooren’s ulcer (36.1%), followed by infectious keratitis (30.6%). Recurrence of fungal keratitis accounted for 81.8% in the failed cases after ALK for infectious keratitis cases. CONCLUSION: Infectious keratitis and keratoconus are the main indications for ALK, of which fungal keratitis was the major cause of corneal infections. Recurrence of primary disease is the main reason of graft failure after ALK, in which the main primary diseases associated with graft failure are Mooren’s ulcer and fungal keratitis.http://www.ijo.cn/en_publish/2018/5/20180511.pdf790anterior lamellar keratoplastyindicationfailureinfectious keratitisMooren’s ulcer |
| spellingShingle | Zhen Wang Xiao-Jun Tan Hua-Lei Zhai Jun Cheng Yan Gao Li-Xin Xie Etiology and failure analysis of anterior lamellar keratoplasty International Journal of Ophthalmology 790 anterior lamellar keratoplasty indication failure infectious keratitis Mooren’s ulcer |
| title | Etiology and failure analysis of anterior lamellar keratoplasty |
| title_full | Etiology and failure analysis of anterior lamellar keratoplasty |
| title_fullStr | Etiology and failure analysis of anterior lamellar keratoplasty |
| title_full_unstemmed | Etiology and failure analysis of anterior lamellar keratoplasty |
| title_short | Etiology and failure analysis of anterior lamellar keratoplasty |
| title_sort | etiology and failure analysis of anterior lamellar keratoplasty |
| topic | 790 anterior lamellar keratoplasty indication failure infectious keratitis Mooren’s ulcer |
| url | http://www.ijo.cn/en_publish/2018/5/20180511.pdf |
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