A Sweet Warning: Mucin-Type O-Glycans in Cancer
Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/22/3666 |
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| author | Yuhan Zhang Lingbo Sun Changda Lei Wenyan Li Jiaqi Han Jing Zhang Yuecheng Zhang |
| author_facet | Yuhan Zhang Lingbo Sun Changda Lei Wenyan Li Jiaqi Han Jing Zhang Yuecheng Zhang |
| author_sort | Yuhan Zhang |
| collection | DOAJ |
| description | Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed. |
| first_indexed | 2024-03-09T18:24:45Z |
| format | Article |
| id | doaj.art-b9f65d48d86e403b8e34f08d0dae7803 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:24:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b9f65d48d86e403b8e34f08d0dae78032023-11-24T07:59:05ZengMDPI AGCells2073-44092022-11-011122366610.3390/cells11223666A Sweet Warning: Mucin-Type O-Glycans in CancerYuhan Zhang0Lingbo Sun1Changda Lei2Wenyan Li3Jiaqi Han4Jing Zhang5Yuecheng Zhang6Medical College of Yan’an University, Yan’an University, Yan’an 716000, ChinaMedical College of Yan’an University, Yan’an University, Yan’an 716000, ChinaDepartment of Gastroenterology, Ninth Hospital of Xi‘an, Xi’an 710054, ChinaMedical College of Yan’an University, Yan’an University, Yan’an 716000, ChinaMedical College of Yan’an University, Yan’an University, Yan’an 716000, ChinaMedical College of Yan’an University, Yan’an University, Yan’an 716000, ChinaKey Laboratory of Analytical Technology and Detection of Yan’an, College of Chemistry and Chemical Engineering, Yan’an University, Yan’an 716000, ChinaGlycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed.https://www.mdpi.com/2073-4409/11/22/3666mucin-type o-glycosylationcancertumor-associated antigens antigentumor therapy |
| spellingShingle | Yuhan Zhang Lingbo Sun Changda Lei Wenyan Li Jiaqi Han Jing Zhang Yuecheng Zhang A Sweet Warning: Mucin-Type O-Glycans in Cancer Cells mucin-type o-glycosylation cancer tumor-associated antigens antigen tumor therapy |
| title | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
| title_full | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
| title_fullStr | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
| title_full_unstemmed | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
| title_short | A Sweet Warning: Mucin-Type O-Glycans in Cancer |
| title_sort | sweet warning mucin type o glycans in cancer |
| topic | mucin-type o-glycosylation cancer tumor-associated antigens antigen tumor therapy |
| url | https://www.mdpi.com/2073-4409/11/22/3666 |
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