Pharmacometrics approaches and its applications in diabetes: An overview
Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling is a step forward in minimizing the risk or a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=335;epage=340;aulast=Aziz |
| _version_ | 1797995534922809344 |
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| author | Sohail Aziz Sabariah Noor Harun Syed Azhar Syed Sulaiman Siti Maisharah Sheikh Ghadzi |
| author_facet | Sohail Aziz Sabariah Noor Harun Syed Azhar Syed Sulaiman Siti Maisharah Sheikh Ghadzi |
| author_sort | Sohail Aziz |
| collection | DOAJ |
| description | Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling is a step forward in minimizing the risk or at least understanding the factors associated to its progression with the passage of time. These models investigate diabetes treatments effects and the progression factors with different viewpoints incorporating insulin-glucose dynamics, dose-response and pharmacokinetics, and pharmacodynamics relationships. Pharmacometrics modeling is an innovative approach in a sense that it is taking us away from the conventional analysis by providing all the opportunities in improving the decision-making in health sector. It has been suggested that we can achieve greater statistical power for determining drug effects through model-based evaluation than through traditional evaluations. The main aim of this review was to evaluate pharmacometrics approaches used in modeling diabetes progression through time and also the integrated models describing glucose-insulin dynamics. |
| first_indexed | 2024-04-11T10:03:16Z |
| format | Article |
| id | doaj.art-b9f6f80b317b491d8efbbd5942d7a33c |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-04-11T10:03:16Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-b9f6f80b317b491d8efbbd5942d7a33c2022-12-22T04:30:19ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062021-01-0113433534010.4103/jpbs.jpbs_399_21Pharmacometrics approaches and its applications in diabetes: An overviewSohail AzizSabariah Noor HarunSyed Azhar Syed SulaimanSiti Maisharah Sheikh GhadziType 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling is a step forward in minimizing the risk or at least understanding the factors associated to its progression with the passage of time. These models investigate diabetes treatments effects and the progression factors with different viewpoints incorporating insulin-glucose dynamics, dose-response and pharmacokinetics, and pharmacodynamics relationships. Pharmacometrics modeling is an innovative approach in a sense that it is taking us away from the conventional analysis by providing all the opportunities in improving the decision-making in health sector. It has been suggested that we can achieve greater statistical power for determining drug effects through model-based evaluation than through traditional evaluations. The main aim of this review was to evaluate pharmacometrics approaches used in modeling diabetes progression through time and also the integrated models describing glucose-insulin dynamics.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=335;epage=340;aulast=Azizdiabetesmodelingpharmacometricsprogression |
| spellingShingle | Sohail Aziz Sabariah Noor Harun Syed Azhar Syed Sulaiman Siti Maisharah Sheikh Ghadzi Pharmacometrics approaches and its applications in diabetes: An overview Journal of Pharmacy and Bioallied Sciences diabetes modeling pharmacometrics progression |
| title | Pharmacometrics approaches and its applications in diabetes: An overview |
| title_full | Pharmacometrics approaches and its applications in diabetes: An overview |
| title_fullStr | Pharmacometrics approaches and its applications in diabetes: An overview |
| title_full_unstemmed | Pharmacometrics approaches and its applications in diabetes: An overview |
| title_short | Pharmacometrics approaches and its applications in diabetes: An overview |
| title_sort | pharmacometrics approaches and its applications in diabetes an overview |
| topic | diabetes modeling pharmacometrics progression |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=335;epage=340;aulast=Aziz |
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