Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study
Despite strontium ranelate use in osteoporosis management being one of the promising concepts in disease treatment, there is no clear evidence that strontium organic compounds are more effective than inorganic ones. The aim of this study was to compare strontium chlorate and strontium ranelate influ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/91 |
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| author | Karolina Turżańska Agnieszka Tomczyk-Warunek Maciej Dobrzyński Maciej Jarzębski Rafał Patryn Joanna Niezbecka-Zając Monika Wojciechowska Aneta Mela Aneta Zarębska-Mróz |
| author_facet | Karolina Turżańska Agnieszka Tomczyk-Warunek Maciej Dobrzyński Maciej Jarzębski Rafał Patryn Joanna Niezbecka-Zając Monika Wojciechowska Aneta Mela Aneta Zarębska-Mróz |
| author_sort | Karolina Turżańska |
| collection | DOAJ |
| description | Despite strontium ranelate use in osteoporosis management being one of the promising concepts in disease treatment, there is no clear evidence that strontium organic compounds are more effective than inorganic ones. The aim of this study was to compare strontium chlorate and strontium ranelate influence on the mice bone microarchitecture. We investigated whether strontium chlorate (7.532 mmol/L) and strontium ranelate (7.78 mmol/L) solutions fed to healthy SWISS growing mice (<i>n</i> = 42) had an influence on the percent of bone volume (BV/TV), trabecular thickness (Tb.Th), number of trabeculae (Tb.N), and separation between each trabecula (Tb.Sp) in the chosen ROI (region of interest) in the distal metaphysis of the left femurs. The cortical bone surface was examined close to the ROI proximal scan. There was an increase in each examined parameter compared with the control group. There were no statistical differences between strontium ranelate and strontium chlorate parameters. Our study indicates that organic and inorganic strontium compounds similarly affect the bone microarchitecture and strength. |
| first_indexed | 2024-03-08T15:00:39Z |
| format | Article |
| id | doaj.art-b9f9b9d7de84448c9b25e460cc8bff83 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T15:00:39Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b9f9b9d7de84448c9b25e460cc8bff832024-01-10T15:05:30ZengMDPI AGNutrients2072-66432023-12-011619110.3390/nu16010091Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary StudyKarolina Turżańska0Agnieszka Tomczyk-Warunek1Maciej Dobrzyński2Maciej Jarzębski3Rafał Patryn4Joanna Niezbecka-Zając5Monika Wojciechowska6Aneta Mela7Aneta Zarębska-Mróz8Department of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, PolandDepartment of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Wojska Polskiego 38/42, 60-637 Poznan, PolandDepartment of Humanities and Social Medicine, Medical University of Lublin, Chodźki 7, 20-093 Lublin, PolandDepartment of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Pediatrics and Nephrology, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDespite strontium ranelate use in osteoporosis management being one of the promising concepts in disease treatment, there is no clear evidence that strontium organic compounds are more effective than inorganic ones. The aim of this study was to compare strontium chlorate and strontium ranelate influence on the mice bone microarchitecture. We investigated whether strontium chlorate (7.532 mmol/L) and strontium ranelate (7.78 mmol/L) solutions fed to healthy SWISS growing mice (<i>n</i> = 42) had an influence on the percent of bone volume (BV/TV), trabecular thickness (Tb.Th), number of trabeculae (Tb.N), and separation between each trabecula (Tb.Sp) in the chosen ROI (region of interest) in the distal metaphysis of the left femurs. The cortical bone surface was examined close to the ROI proximal scan. There was an increase in each examined parameter compared with the control group. There were no statistical differences between strontium ranelate and strontium chlorate parameters. Our study indicates that organic and inorganic strontium compounds similarly affect the bone microarchitecture and strength.https://www.mdpi.com/2072-6643/16/1/91strontium ranelatestrontium chloridegrowing micebone microarchitecturemicrotomography |
| spellingShingle | Karolina Turżańska Agnieszka Tomczyk-Warunek Maciej Dobrzyński Maciej Jarzębski Rafał Patryn Joanna Niezbecka-Zając Monika Wojciechowska Aneta Mela Aneta Zarębska-Mróz Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study Nutrients strontium ranelate strontium chloride growing mice bone microarchitecture microtomography |
| title | Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study |
| title_full | Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study |
| title_fullStr | Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study |
| title_full_unstemmed | Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study |
| title_short | Strontium Ranelate and Strontium Chloride Supplementation Influence on Bone Microarchitecture and Bone Turnover Markers—A Preliminary Study |
| title_sort | strontium ranelate and strontium chloride supplementation influence on bone microarchitecture and bone turnover markers a preliminary study |
| topic | strontium ranelate strontium chloride growing mice bone microarchitecture microtomography |
| url | https://www.mdpi.com/2072-6643/16/1/91 |
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